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Key research insights behind NMN, fisetin and spermidine.
NMN
A study found that elderly men who supplemented with 250 mg/day of NMN for 12 weeks experienced moderate improvements in muscle performance—specifically in gait speed and grip strength—compared to those in the placebo group.
Spermidine (Yuth™)
Levels and the body’s ability to absorb it decline with age. Evidence suggests that healthy levels of this compound are associated with healthy aging and longevity.
Fisetin
Has strong antioxidant activity and supports cellular health pathways related to healthy aging.
NMN — The Direct NAD+ Precursor
Engineered for fast uptake and powerful cellular support.
Prime™ NMN is formulated with the biologically active form of NMN (β-type) shown to effectively support NAD+ biosynthesis. Among common NAD+ precursors, NMN sits the closest, being only one step away in the biochemical pathway to produce NAD+. Additionally, NMN has been shown to be more quickly absorbed by the gut and the body’s tissues, and this bioavailability is why it is recognized today as one of the most effective and efficient NAD+ precursors for jumpstarting cellular energy and supporting cellular NAD+ levels.
The Prime™ Approach to Cellular Support
Designed to fuel cellular vitality through multiple supportive pathways.
Prime™ NMN harnesses cutting-edge science with a powerful combination of the powerful NAD+ precursor, NMN, and innovative ingredients like Yuth™ and fisetin. This power trio of ingredients works in harmony to supercharge cellular health at the foundation while supporting the body’s antioxidant defenses.
Product Classification
Good Manufacturing Practices
Vegan
No Detectable GMO
Gluten-Free
Key Ingredients & Benefits
Supports Muscle Performance with Age
Supports energy production in muscle tissue
Supports Cognitive Function
Spermidine may also be effective for supporting cognitive function and brain health.
In various animal studies, fisetin has been shown to support cognitive functioning.
Helps Maintain Metabolic Health
Spermidine is associated with healthy metabolic health.
Supports Antioxidant Activity
Fisetin helps combat free radicals and defend our cells against oxidative stress.
Spermidine and NMN support the body’s antioxidant defense systems.
Supports Cellular Energy
NMN supports NAD+ metabolism, a cofactor essential for cellular ATP production.
Research shows NMN supports NAD+ blood levels.
Fisetin helps maintain mitochondrial functioning and cellular energy production.
Spermidine supports overall cellular balance for efficient energy use.
Supports Healthy Aging
NMN helps maintain NAD+ levels that decline with age.
Healthy levels of spermidine are associated with healthy aging and longevity.
The Future of Cellular Energy Starts Here
Keeping your cellular NAD+ levels at their peak is essential for vibrant energy, optimal mitochondrial function and healthy aging. Prime™ NMN harnesses cutting-edge science with a powerful combination of the powerful NAD+ precursor, NMN, and innovative ingredients like Yuth™ and fisetin. This power trio of ingredients works in harmony to supercharge cellular health at the foundation while supporting the body’s antioxidant defenses. Prime™ NMN positions itself at the forefront of next-generation wellness, empowering you to proactively support your long-term cellular health, combat the signs of aging and unlock your body’s true potential.
Frequently Asked Questions
How do Prime™ NMN and Prime™ NAD+ work differently to support NAD+ production?
NMN is one step closer along the pathway to NAD+ than NR is. NR -> NMN -> NAD+. NMN -> NAD+.
Will I benefit from taking both Prime™ NMN and Prime™ NAD+ together?
Yes, NMN and NR supplementation support NAD+ levels in the body through different pathways. NMN is one step closer to NAD⁺ than NR. Pairing Prime™ NAD+ (formulated with NR and pterostilbene) with Prime™ NMN (formulated with NMN, fisetin and Yuth™—spermidine) could offer a broader longevity-supporting profile, exceeding NAD⁺ support.
What other products pair well with Prime™ NMN?
Isotonix OPC-3® helps support oxidative balance, while Isotonix® Activated B Complex can help ensure all B vitamins and cofactors are present for NAD+ metabolism. Heart Health™ Advanced Co-Q10 (Cardiovascular & Immune Support Formula) is another product that works well alongside Prime™ NMN. Heart Health Advanced Co-Q10 is vital for cellular energy (ATP) production and mitochondrial health. CoQ10 serves as a free radical scavenger and an antioxidant and, when paired with NMN, it can help promote cellular energy and metabolism.
If I already take Prime™ NAD+, should I switch to Prime™ NMN?
Both products support NAD+ production; the choice comes down to your personal and formulation preference.
What is the ideal daily supplementation amount to acquire anti-aging benefits?
Many clinical studies use around 500 mg of NMN. Consistency appears important because NAD+ levels decline after stopping supplementation.
When is the best time to take Prime™ NMN?
Most users take it in the morning with food, as NAD+ levels fluctuate with circadian rhythm and energy demand. It’s okay to take it later in the day, but the best results are likely in the morning.
Does this product provide the same benefits to men and women?
Current evidence suggests that supplementing with NR or NMN NAD+ precursors provides the same benefits for both men and women. Benefits are more related to age than gender. However, various studies have revealed evidence that men tend to have slightly higher baselines of NAD+ in their blood. One study also revealed that men tended to have a more linear downslope trend of NAD+ levels with age, whereas women’s levels showed a trend of fluctuation of NAD+ whole blood levels. While the exact reason for this is still unknown, one speculation is that it may be due to females’ hormones. Therefore, men may benefit from having higher NAD+ levels than women initially, but their downward trend of NAD+ levels suggests they may age more progressively.
Aside from aging, what else can deplete NAD+ levels in the body?
Regardless of age, certain lifestyle factors may influence the body’s nutritional needs, including those related to NAD-related metabolic processes. Habits such as smoking, alcohol consumption, low physical activity, excess weight, inadequate sleep, and poor dietary patterns are commonly associated with overall metabolic and cellular health.
What are NAD+ precursors?
Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN) and the non-vitamin B derivative tryptophan (Trp), are known as precursors of NAD+, meaning they support the production of NAD+.
How is NMN absorbed so quickly?
Research indicates that NMN taken orally is absorbed rapidly—often within minutes—and shortly after ingestion, it supports the production of NAD+ in various tissues. Animal research has identified a specific NMN-transporter, Slc12a8, which is responsible for facilitating the rapid uptake of NMN for immediate utilization in NAD+ biosynthesis. However, studies are still being done to see if this is the same for humans.
*This product is not intended to diagnose, treat, cure or prevent any disease.
‡Yüth™ is a trademark of Compound Solutions, Inc.
