Gluten-Free – The finished product contains no detectible gluten (<10ppm gluten)

Vegan – The product is made without any ingredients produced by or derived from animals

No Detectable GMOs – The finished product contains no detectable genetically-modified organisms. 

Quality Standards – GMP Operations and Standardized Ingredients

Checked For – Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency and Identity

Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its aging process: nicotinamide adenine dinucleotide (NAD+). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD+ and its metabolic counterpart NADH are what the cell relies on for life.

These compounds hold the key to supporting healthy metabolism and aging. NAD+ is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of ATP production within the cells, promoting cellular regeneration and supporting healthy mitochondrial metabolism. Each serving of Prime  NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD+ levels within our cells. NAD+ is connected to one’s health, youth and quality of life; you simply cannot live without it since it is essential for cellular life.⁵ Cellular health is associated with our physical and cognitive health and overall well-being. Prime NAD+ is a gluten-free, non-GMO formula that works to support healthy NAD+ production and helps maintain NAD+ levels in aging adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD+. Whether you are looking to combat the natural age-related decline of NAD+ levels or support NAD+ levels for those living NAD+-depleting lifestyles, Prime NAD+ may help you sustain a healthy reservoir of the youthful NAD+ molecule.

NAD+ is naturally occurring, residing in every living cell in the body and has been shown to be strongly linked to cellular health. Various sources of vitamin B3 are known as precursors of NAD+, meaning they influence or help build upon the production of NAD +. The balance between the consumption and synthesis of NAD+ plays into the replenishment or concentration levels of NAD+ within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD+ precursors into NAD+ for our cells. Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing the pools of NAD+ in our cells. NAD+, the oxidized form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD+ /NADH redox ratio, which provides insight as to how well our cells are creating energy or ATP and portrays the current condition of cellular health and metabolism. NAD +-depleting lifestyles can negatively impact this ratio, and imbalances of this ratio are associated with cellular aging. Consuming more NAD+ precursors to promote the increase of NAD+ may help you to maintain a healthy balance of this ratio.

Younger people naturally have higher NAD+ reserves in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of aging as their age group are also linked to having higher pools of NAD+. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD+ production begins to decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD+ levels. Other cellular pools also are impacted by age and the loss of NAD+; such as mitochondria, adipose tissue and muscle- emphasizing that NAD+ a crucial part of healthy aging. Prime NAD+ is formulated with NR and pterostilbene, both of which have scientifically proven their ability to support cellular health. A study analyzing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase of NAD+ levels. When analyzing concentration of NAD+ levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group administered a double serving showed a 90% increase of NAD+ levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days.

While supplementation of NAD+ precursors can promote an extra reserve of NAD+, it is NAD+ itself that really does the heavy lifting and influences all the different working parts of the cell that may help to safeguard you from the inevitable cellular aging process. One influencing factor is the promotion of Sirtuins (SIRTs) activity, also known as the longevity genes. These genes are age-defying enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. One of SIRTs’ primary roles is helping our cells detoxify by sweeping out the bad elements and reusing the good for repair, ultimately supporting cellular youth at its core. Prime NAD+ promotes the normal activity of the SIRT-1 gene, a treasured gene that protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-aging pathways, and the modulation of a whirlwind of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. When our DNA becomes damaged, it can deplete the cell’s NAD+ levels, leading to a decrease in sirtuin activity. Therefore, stockpiling a healthy amount of NAD+ naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health.

While maintaining healthy NAD+ production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomers. Telomers are genome-protective caps located at the end of chromosomes: they act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying or getting damaged. These little caps can indicate the age or lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomers become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Evidence shows that shorter telomers contain lower NAD+ levels. Just as NAD+ levels decrease with age, telomers naturally shorten with age and both are correlated with the health of the cells and their ability to support cellular repair and regeneration. Studies suggest that taking both NR and pterostilbene together can support each other's bioavailability, or their ability to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene also acts as the golden sword for the aging mind, as the autophagy-influencing antioxidant supports the mediation of SIRT-1 and SIRT-2, which are directly linked to helping maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91 minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period.

Regardless of age, poor lifestyle habits such as smoking, drinking, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD+, which could make NAD+-promoting supplementation beneficial for even those who are considered to be younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene may support our overall well-being and bring you one step further to supporting you hack the aging process. With Prime NAD+ on your side, The golden age is before us, not behind us. You don’t have to wait until you are older to start caring about aging.

To ensure the best quality, please remember to:
1. Store Prime NAD+ in a cool, dry place.
2. After opening the jar, it’s important to keep the desiccant pillow inside and replace the screw cap immediately after removing your capsules.
If these guidelines are not followed, discoloration of the capsules may occur due to moisture absorption. Rest assured, discoloration does not affect the potency, safety, or effectiveness of the product.

*This product is not intended to diagnose, treat, cure, or prevent any disease.

Nicotinamide Riboside (crystalline nicotinamide riboside chloride): 250 mg
Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD+. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD+. NAD+ is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying elections between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.

Pterostilbene: 50 mg
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.

1. What are NAD+ precursors?
   Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN), and tryptophan (Trp), are known as precursors of NAD+, meaning they influence or help build upon the production of NAD+.
   
   
2. How was NAD+ discovered?
   NAD+ was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolize sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD+ molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD+ and identified responsible enzymes. The pathway that converts nicotonic acid to NAD+ is named the Preiss-Handler pathway.
   
   
3. What are the two factors that play into the continuous replenishment of NAD+ in the cells?
   The consumption and synthesis of NAD+ are two factors that play into the replenishment or concentration levels of NAD+ within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD+ precursors convert into NAD+ for the body’s cells. The NAD+ precursor NR is specifically linked to the salvage pathway.
   
   
4. What is NAD+/NADH redox ratio?
   NAD+ is recognized as the oxidized form of nicotinamide adenine dinucleotides whereas NADH is the reduced form. Overall, the NAD+/NADH redox ratio explains how well the cells are creating energy or ATP, portraying the current condition of cellular health and metabolism. NAD+-depleting lifestyles can negatively impact this ratio, throwing it off balance and leading to a decreased ratio which is also associated with age. Consuming more NAD+ precursors which help increase levels of NAD+ is effective for helping to maintain a healthy balance of this ratio.
   
   
5. What can deplete NAD+ levels in the body other than aging?
   Regardless of age, young or rough lifestyle habits can contribute to the increased need of NAD+. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD+ depletion.
   
   
6. What foods contain NAD+ precursors or naturally assist in promoting NAD+?
   Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD+ precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD+ levels.
   
   
7. What are other ways you can promote sirtuin activity?
   Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, the youthful, antioxidant-rich, stress-fighting molecule, sirtuin activity can also be promoted by supplementing with resveratrol and curcumin. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins.
   
   
8. What are telomers?
   Telomers are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomer in length, the better. Telomers are like the clear coating at the end of the shoelace string that keeps the lace from fraying or getting damaged; each time your cells divide, the chromosomal telomers become shorter and over time result in a damaged cell or death of the cell. Where maintaining healthy NAD+ production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomers. Evidence shows that shorter telomers contain lower NAD+ levels. Just as NAD+ levels decrease with age, telomers naturally shorten with age and both are correlated with the health of the cells and their ability to support cellular repair and regeneration.
   
   
9. What is the goal of Prime NAD+?
   While all our Prime products are crafted to promote healthy aging at every level (including vision health, vascular strength, joint or hormone support), Prime NAD+ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD+ molecule to help combat the cellular aging process.
   
   
10. How long does someone need to take this product to reach optimal levels of NAD+?
    The average time it may take someone to reach optimal NAD+ levels when taking this product is anywhere between two weeks and 30 days.
    
    
11. How does Prime NAD+ differ from Heart Health™ Advanced Co-Q10 on a cellular level?
    With age, the body produces less Co-Q10 naturally; Heart Health Advanced Co-Q10 provides additional Co-Q10 to the body which helps generate energy in every cell of the human body and promotes cardiovascular health. Prime NAD+ is not a short-lived type of energy supplement but an energy supplement for cellular longevity and vitality. 
    
    
12. How do Prime NAD+ and Heart Health Advanced Co-Q10 work differently to support cell functioning?
    NAD+ is the spark that initiates what is called electron-transport chain, which is required to manufacture adenosine triphosphate (ATP) or the energy currency of our cells; it is cellular energy at its core and the spark of human metabolism. Heart Health Advanced Co-Q10 contains coenzyme Q10, which acts as a necessary fuel product for mitochondrial generation. Co-Q10 safeguards the mitochondria from oxidative stress and helps create a healthy environment for mitochondrial activity. In short, NAD+ is the literal spark for energy, where Co-Q10 is the fuel. 
    
    
13. What is the half-life of pterostilbene in comparison to resveratrol?
    Pterostilbene has a much longer half-life (105 minutes) than resveratrol (14 minutes), meaning that pterostilbene is actively working in your system to provide health benefits for a longer time.
    
    
14. What are the directions of use for this product?
    Adults, take 2 capsules every morning with or without food. This supplement is meant to be taken only once a day.
    
    
15. Are there any warnings for this product?
    If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Do not take this product if you are pregnant or breastfeeding.
    
    
16. How should I store Prime NAD+?
    To ensure the best quality, please remember to:
    1) Store Prime NAD+ in a cool, dry place. 
    2) After opening the jar, it’s important to keep the desiccant pillow inside and replace the screw cap immediately after removing your capsules.
    If these guidelines are not followed, discoloration of the capsules may occur due to moisture absorption. Rest assured, discoloration does not affect the potency, safety, or effectiveness of the product. 
    
    
17. Is this product vegetarian or vegan?
    This product is suitable for vegetarians and vegans as it is from a synthetic source, but it cannot be certified as vegan or vegetarian.
    
    
18. Is Prime NAD+ safe?
    The product is safe and free of harmful agents. The product is made in the United States in FDA-inspected facilities using Good Manufacturing Practices. Customers can have confidence in the quality and safety of this product.

*This product is not intended to diagnose, treat, cure, or prevent any disease.

1. Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD⁺ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
2. Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
3. Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD⁺ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
4. Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD⁺ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
5. What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
6. Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD⁺ Metabolome Is Dysregulated in 'Normal' Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
7. Grabowska, W., Sikora, E. & Bielak-Zmijewska, A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476 (2017). https://doi.org/10.1007/s10522-017-9685-9
8. Ruszkiewicz, J. A., Bürkle, A., & Mangerich, A. (2022). Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity. Journal of Biological Chemistry, 298(6), 102037. https://doi.org/10.1016/j.jbc.2022.102037
9. Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
10. Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle . https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
11. Ng, F., Wijaya, L., & Tang, B. L. (2015). SIRT1 in the brain—connections with aging-associated disorders and lifespan. Frontiers in Cellular Neuroscience, 9. https://doi.org/10.3389/fncel.2015.00064
12. ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
13. Omran, H. M., & Almaliki, M. S. (2020). Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis. Journal of Infection and Public Health, 13(9), 1196–1201. https://doi.org/10.1016/j.jiph.2020.06.004
14. Stock, A. J., & Liu, Y. (2021). NAD-Linked Metabolism and Intervention in short telomere syndromes and murine models of telomere dysfunction. Frontiers in Aging, 2. https://doi.org/10.3389/fragi.2021.785171
15. Shammas M. A. (2011). Telomeres, lifestyle, cancer, and aging. Current opinion in clinical nutrition and metabolic care, 14(1), 28–34. https://doi.org/10.1097/MCO.0b013e32834121b1
16. Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
17. Aman Y, Qiu Y, Tao J, Fang EF. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging. 2018 Jan 1;2:30-7.
18. Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
19. Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
20. Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
21. Cantó, C.; Houtkooper, R.H.; Pirinen, E.; Youn, D.Y.; Oosterveer, M.H.; Cen, Y.; Fernandez-Marcos, P.J.; Yamamoto, H.; Andreux, P.A.; Cettour-Rose, P.; et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012, 2012. 15, 838–847.
22. Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of aging. 2012 Sep 1;33(9):2062-71.
23. Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T. Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling. Free Radical Biology and Medicine. 2021 Dec 1;177:1-4.
24. Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
25. de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
26. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
27. Elhassan, Y. S., Kluckova, K., Fletcher, R. S., et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Reports. 2019.
28. Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
29. Felici R, Lapucci A, Cavone L, Pratesi S, Berlinguer-Palmini R, Chiarugi A. Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts s. MOLECULAR PHARMACOLOGY. 2015 Jun;87:965-71.
30. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003.
31. Imai S, Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, Obesity and Metabolism. 2013;15(3):26-33.
32. Joseph JA, Fisher DR, Bielinski D, Rimando A, Shukitt-Hale B, Michael Barger W, Romeno S, Smith MA, Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Ann N Y Acad Sci. 2004
33. Kang, H. T., & Hwang, E. S. Nicotinamide enhances mitochondria quality through autophagy activation in human cells. Aging Cell. 2009.
34. Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
35. Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
36. McCormack D, McFadden D. A Review of Pterostilbene Antioxidant Activity and Disease Modification.
37. Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
38. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism. 2016 Dec 13;24(6):795-806.
39. Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
40. Naylor S, Williamson D, Reeve A, Smith MA, Battcher K, Rando TA. A Review of the Effects of Berries and Pterostilbene on Aging and Age-Related Diseases: An Update. Antioxid Redox Signal 2020.
41. Pittelli M, Felici R, Pitozzi V, Giovannelli L, Bigagli E, Cialdai F, Romano G, Moroni F, Chiarugi A. Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis. MOLECULAR PHARMACOLOGY. 2011;80(6):1136-46.
42. Cerutti, E. Pirinen, C. Lamperti, S. Marchet, Anthony A. Sauve, W. Li, V. Leoni, Eric A. Schon, F. Dantzer, J. Auwerx, C. Viscomi, M. Zeviani, NAD+-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease, Cell. Metab. 19(6) (2014) 1042-1049.
43. Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Agric. Food Chem. 2002.
44. Samuel Trammell et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948. doi: 10.1038/ncomms12948.
45. Sophia E Airhart et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One.2017 Dec 6;12(12):e0186459. doi: 10.1371/journal.pone.0186459.
46. Suárez-Rivero, J. M., et al. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases. Front. Pharmacol. 13: 862085. doi: 10.3389/fphar (2022).
47. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K. NAD repletion improves mitochondrial and stem cell function and enhances life span in mice.
48. Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients. 2020 Jun;12(6).
49. Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
50. Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
51. Naylor S, Williamson D, Reeve A, Smith MA, Battcher K, Rando TA. A Review of the Effects of Berries and Pterostilbene on Aging and Age-Related Diseases: An Update. Antioxid Redox Signal 2020.