• Helps support a healthy intestinal lining
• Supports mucus membranes of the GI tract
• Supports a healthy intestinal barrier
• Helps support digestive, gut, and gastrointestinal health
• Supports intestinal and colonic permeability Supports a healthy and balanced microbiome
• Supports cognitive health

Gluten-Free – The finished product contains no detectible gluten (<10 ppm gluten)

Vegan – The product is made without any ingredients produced or derived from animals

No Detectable GMOs – The finished product contains no detectable genetically-modified organisms

Checked For – Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

The gut and our central nervous system are intertwined, and together have a direct impact on the body’s emotional state, metabolism, and immune function. For this reason, the gut is often referred to as the second brain as it plays a key role in our overall physical, mental and metabolic wellbeing. The gut microbiota, or the community of microorganisms within your intestines, both small and large, vary in bacterial abundance as well as function. In other words, biodiversity and a proper ratio of the bacteria in the gut are critical to the functioning of the body and its metabolism.

The microorganisms that live in our gut affect how the body functions cognitively and physiologically, influencing the overall workings of the body and the body’s ability to maintain healthy cardiovascular, immune and nervous systems. Meanwhile, the foods we consume, particularly good fat and fiber, create the proper environment for this intestinal ecosystem to thrive. Fiber rich foods (such as resistant starches or prebiotics) remain undigested until they reach the large intestine, they are the source of incredible energy and hormone signaling as they are broken down by bacteria through fermentation. This process creates healthy bacterial diversity and subsequent, called postbiotics or short-chain fatty acids (SCFAs) which are a preferred metabolic energy source for the intestines as well as the immune, vascular and nervous systems throughout the body. While probiotics create a local environment in the small and large bowel, SCFAs create a systemic approach to metabolic energy balance in the form of healthy digestion, immune, cognitive and cardiovascular function. This is referred to as the gut-brain axis and its preferred interactive components are SCFAs, one of which is butyrate. Higher levels of dietary fiber intake contribute to an increase in the production of butyrate, one of the main energy sources for colonocytes and intestinal cells that make up your gut lining. Scientific studies show that supplementing with a direct butyrate promotes postbiotic SCFA production, supporting a healthy microbiome for metabolic health.

In addition to eating a fiber-rich diet, supplementing with direct short-chain fatty acids such as butyrate, propionate or acetate can support the microbiome’s diversity and gut barrier function. Maintaining healthy metabolic functioning relies on healthy food choices, lifestyle habits and supplementation. SCFAs can help the body perform at its best metabolically. Prime^™ Advanced Digestive Support (With Postbiotics & Berberine) provides a botanical blend of amino acid-derived fatty acids, CoreBiome^™ (Tributyrate) and Berberine to supports ongoing SCFA production within the intestine.

Prime^™ Advanced Digestive Support (With Postbiotics & Berberine) delivers 600 mg of the clinically studied ingredient CoreBiome^™ (containing three molecules of butyrate), in combination with 150 mg of Berberine to help the microbiome through the support of healthy intestinal and colonic permeability. The ingredient of CoreBiome^™, the butyrate acting SCFA, is highly bioavailable or easily absorbed by the colon, encouraging the production of colonocytes. Butyrate is a unique signaling molecule that has receptors in nearly all cells and is an important aspect of colonocyte metabolism. These little colonocytes are desired by the colon for providing an oxygen-free environment for the beneficial microbes to flourish and support the thickness and health of the intestinal walls. When the SCFA production of acetate and propionate outweighs the SCFA butyrate production it can interfere with the colon’s ability to metabolize. Thus, healthy levels of butyrate can help maintain a healthy metabolism of gut and microbes, whereas a lack of healthy colonocyte production may make it more difficult for the microbiome to carry out the ability to maintain homeostasis.

Prime^™ Advanced Digestive Support (With Postbiotics & Berberine)’s ingredients, CoreBiome^™ and Berberine, also have a promoting factor in the production of the two gut bugs known as Faecalibacterium prausnitzii (specific to butyrate production) and Akkermanssia muciniphila (supported by the prebiotic acting ingredient, Berberine). Berberine is essential for supporting the increase of the good bacteria that aid in butyrate production, while butyrate serves as an important by-product produced from the probiotic. Prime^™ Advanced Digestive Health’s unique ingredient, Berberine, helps maintain a healthy microbial balance in the large intestine. Being one of the richest bacteria residing in the intestine, Akkermanssia muciniphila is an important microbe of the intestine’s metabolic process.

Prime^™ Advanced Digestive Support (With Postbiotics & Berberine) was crafted with ingredients that help support the continual production of the body’s SCFA postbiotics to help support a healthy environment for the microbiome to thrive. The food we put in our body and the way we treat it can affect the way we perform. In addition to genetics, a diet lacking in fiber, consuming too many processed foods, age or a slowing metabolism, lack of sleep and exercise can also be contributing factors associated with a decrease in the body’s natural production of postbiotic SCFAs. As Shakespeare warns, Things sweet to taste prove indigestion sour. Metabolism may change with age, but your digestion does not have to.

Your gut health is not what it used to be! Optimizing gut health from start to finish.

^* This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

^ŧ CoreBiome^™ is a trademark of Compound Solutions, Inc.

CoreBiome™ (Tributyrate): 600 mg
CoreBiome is a derivative of butyrate, which is a byproduct of the microbiota in our gut. A great source of butyrate is derived from the vegetables we eat, which nourish our bodies with fiber. However, the body cannot break down the fibers as it moves through the digestive tract. This is where the microbiota step in – to break down these fibers that then ferment into butyrate, one of many short-chain fatty acids. SCFA support a healthy and balanced microbiome. By maintaining a healthy digestive environment and healthy intestinal barrier and permeability, butyrate plays a great role in supporting digestive, gut, and gastrointestinal health. CoreBiome is a great option for the picky eaters that may not consume optimal amounts of vegetables, and it is extra support for those who already do.

Berberine: 150 mg
Berberine is an isoquinoline plant alkaloid found in a variety of plants including barberry, Oregon grape, goldenseal, goldthread, and tree turmeric (Berberis aristate), with its history of use dating back to Ayurvedic and Chinese medicine. Berberine may support the production of akkermansia, a beneficial bacterium that has been reported to maintain healthy intestinal mucus secretion and thus support the intestinal barrier.

1. What good bacteria in the gut are associated with butyrate SCFA production?
   Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii and Roseburia spp. ^{(2, 4)}

2. Who would benefit from this product?
   Those are lack of fiber in diet, looking for digestive support and balanced gut microbiome, or individuals who are looking for extra boost with other digestive support supplements.

3. What is the difference between a prebiotic, probiotic and a post-biotic?
   Prebiotics are fiber or resistant starches that the body cannot digest. Instead, they are the fuel for probiotics and help support the growth of healthy bacteria in the gut. Probiotics are supplied by supplementation or by eating foods that are fermented, such as sauerkraut, kefir, yogurt, goat cheese or kimchi, and produced in the gut as fiber goes through the fermentation process within the large intestine. These good bacteria manufacture beneficial vitamins to prevent bad bacteria from entering the blood, which helps the body digest food by breaking its own for absorption. Postbiotics are short-chain fatty acids (SCFAs) that may assist in stabilizing cholesterol and blood pressure. An imbalance in the microbiome can result in dysbiosis and affect your overall health. A well-balanced diet can help support your body’s beneficial bacteria, but supplementation may also be helpful to maintain regularity.

4. What other products would pair well with this supplement?
   Probiotics-10, Ultimate Aloe, NutriClean Advanced Fiber Powder or Isotonix® Complete Greens Powder Drink would pair well with this supplement to better support overall digestive and wellbeing.

5. What are the three most common short-chain fatty acids (postbiotic metabolites) that are essential to the gut?
   Butyrate, acetate and propionate. The cells in the lining of the gut require butyrate to function properly. Butyrate gives energy to colonocytes (cells in the gut lining) which maintain an oxygen-free environment for beneficial gut microbes to thrive. Keeping gut cells and bacteria happy and healthy. Acetate, the most abundantly produced by the gut, helps maintain the pH and keep gut acid levels low. Propionate assists in the production of glucose in the liver.

6. Why does the aging body benefit from butyrate?
   Over time the gut microbiome diversity changes. This results in one needing to pay more attention to proper diet, exercise and proper hydration. Even with a healthy diet, it may be necessary to supplement the gut to retain postbiotics such as butyrate to maintain a healthy gut lining.

7. Why should I use this product if I already have a high-fiber diet?
   Although a high-fiber diet is an excellent foundation for gut health, adding this product with Butyrate and Berberine may provide additional benefits for those with specific health concerns or individual needs beyond just a high-fiber intake. The synergistic effects of this product can help provide more comprehensive support for gut function, immunity, and metabolic regulation compared to a high-fiber diet alone.

8. Are there any warnings associated with this product or the product’s ingredients?
   Prime^™ Advanced Digestive Support (With Postbiotics & Berberine) is intended for adults 18 years and older. CoreBiome^™ and Berberine are ingredients that are intended to maintain a healthy gut microbiome. Do not take if you are allergic to any of the ingredients or are pregnant or breastfeeding. As with any change in supplementation, consult your primary physician before using.
   
   

• Dong, C., Yu, J., Yang, Y., Zhang, F., Su, W., Fan, Q., Wu, C., & Wu, S. (2021). Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion. Biomedicine & Pharmacotherapy, 139, 111595. https://doi.org/10.1016/j.biopha.2021.111595
• Rivière, A., Selak, M., Lantin, D., Leroy, F., & De Vuyst, L. (2016). Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Frontiers in microbiology, 7, 979. https://doi.org/10.3389/fmicb.2016.00979
• Cani, P. D., & de Vos, W. M. (2017). Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Frontiers in microbiology, 8, 1765. https://doi.org/10.3389/fmicb.2017.01765
• Robinson, M. (2022, March 9). CoreBiome® Tributyrin: The Source of Wellness. Compound Solutions. https://compoundsolutions.com/CoreBiome®-tributyrin-the-source-of-wellness/
• Ma, N., Tian, Y., Wu, Y. and Ma, X., 2017. Contributions of the Interaction Between Dietary Protein and Gut Microbiota to Intestinal Health. Current Protein and Peptide Science, 18, pp.795-808.
• Sauer J., Richter K.K., Pool-Zobel B.L. Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem. 2007;18:736–745.
• Stilling, R. et al. The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain-axis? Neurochemistry International 99 (2016) 110–132.
• Topping D.L., Clifton P.M. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001;81:1031–1064.
• Naito, Y., Uchiyama, K., & Takagi, T. (2018). A next-generation beneficial microbe: Akkermansia muciniphila. Journal of clinical biochemistry and nutrition, 63(1), 33–35. https://doi.org/10.3164/jcbn.18-57