Unlock the Secret to Healthy Aging
4-Week Study of NR & Pterostilbene Supplementation Findings, measuring the concentration of NAD levels in blood:
40%
increase in NAD levels in those who took the recommended serving of supplementation
90%
increase in NAD levels in those who took double the recommended amount of supplementation
60%
Pterostilbene is 60% more bioavailable than resveratrol and has a 91 minute longer half-life than resveratrol

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing the pools of NAD+ in our cells.

Product Classification

Vegan

Gluten-Free

Non-GMO

Good Manufacturing Practices
Key Ingredients & Benefits

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
A form of vitamin B3 that functions as a precursor to NAD+
Influence or help build upon the production of NAD+

Pterostilbene
A naturally occurring compound synthesized in plants
Exhibit antioxidant properties
Helps neutralize harmful free radicals and oxidative stress
The Fountain of Youth
Cutting-edge science that renews cells and DNA so you are energized, mentally sharp, and look and feel younger. Whether fighting aging or coping with a demanding lifestyle, reclaim your spark and thrive with Prime NAD+!
Frequently Asked Questions
What are NAD+ precursors?
Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN), and tryptophan (Trp), are known as precursors of NAD+, meaning they influence or help build upon the production of NAD+.
What are the two factors that play into the continuous replenishment of NAD+ in the cells?
The consumption and synthesis of NAD+ are two factors that play into the replenishment or concentration levels of NAD+ within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD+ precursors convert into NAD+ for the body’s cells. The NAD+ precursor NR is specifically linked to the salvage pathway.
What can deplete NAD+ levels in the body other than aging?
Regardless of age, young or rough lifestyle habits can contribute to the increased need of NAD+. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD+ depletion.
What foods contain NAD+ precursors or naturally assist in promoting NAD+?
Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD+ precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD+ levels.
What are other ways you can promote sirtuin activity?
Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, the youthful, antioxidant-rich, stress-fighting molecule, sirtuin activity can also be promoted by supplementing with resveratrol and curcumin. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins.
What are telomers?
Telomers are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomer in length, the better. Telomers are like the clear coating at the end of the shoelace string that keeps the lace from fraying or getting damaged; each time your cells divide, the chromosomal telomers become shorter and over time result in a damaged cell or death of the cell. Where maintaining healthy NAD+ production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomers. Evidence shows that shorter telomers contain lower NAD+ levels. Just as NAD+ levels decrease with age, telomers naturally shorten with age and both are correlated with the health of the cells and their ability to support cellular repair and regeneration.
How long does someone need to take this product to reach optimal levels of NAD+?
The average time it may take someone to reach optimal NAD+ levels when taking this product is anywhere between two weeks and 30 days.
How should I store Prime NAD+?
To ensure the best quality, please remember to: 1) Store Prime NAD+ in a cool, dry place. 2) After opening the jar, it’s important to keep the desiccant pillow inside and replace the screw cap immediately after removing your capsules. If these guidelines are not followed, discoloration of the capsules may occur due to moisture absorption. Rest assured, discoloration does not affect the potency, safety, or effectiveness of the product.
Is this product vegetarian or vegan?
This product is suitable for vegetarians and vegans as it is from a synthetic source, but it cannot be certified as vegan or vegetarian.
Is Prime NAD+ safe?
The product is safe and free of harmful agents. The product is made in the United States in FDA-inspected facilities using Good Manufacturing Practices. Customers can have confidence in the quality and safety of this product.
Research Scope
Scientific Reference List
- Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
- Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445.
- Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9
- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
- What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
- Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in 'Normal' Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
- Grabowska, W., Sikora, E. & Bielak-Zmijewska, A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology 18, 447–476 (2017). https://doi.org/10.1007/s10522-017-9685-9
- Ruszkiewicz, J. A., Bürkle, A., & Mangerich, A. (2022). Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity. Journal of Biological Chemistry, 298(6), 102037. https://doi.org/10.1016/j.jbc.2022.102037
- Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
- Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle . https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
- Ng, F., Wijaya, L., & Tang, B. L. (2015). SIRT1 in the brain—connections with aging-associated disorders and lifespan. Frontiers in Cellular Neuroscience, 9. https://doi.org/10.3389/fncel.2015.00064
- ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
- Omran, H. M., & Almaliki, M. S. (2020). Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis. Journal of Infection and Public Health, 13(9), 1196–1201. https://doi.org/10.1016/j.jiph.2020.06.004
- Stock, A. J., & Liu, Y. (2021). NAD-Linked Metabolism and Intervention in short telomere syndromes and murine models of telomere dysfunction. Frontiers in Aging, 2. https://doi.org/10.3389/fragi.2021.785171
- Shammas M. A. (2011). Telomeres, lifestyle, cancer, and aging. Current opinion in clinical nutrition and metabolic care, 14(1), 28–34. https://doi.org/10.1097/MCO.0b013e32834121b1
- Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
- Aman Y, Qiu Y, Tao J, Fang EF. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging. 2018 Jan 1;2:30-7.
- Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84.
- Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74.
- Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1).
- Cantó, C.; Houtkooper, R.H.; Pirinen, E.; Youn, D.Y.; Oosterveer, M.H.; Cen, Y.; Fernandez-Marcos, P.J.; Yamamoto, H.; Andreux, P.A.; Cettour-Rose, P.; et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012, 2012. 15, 838–847.
- Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiology of aging. 2012 Sep 1;33(9):2062-71.
- Chen Y, Zhang H, Ji S, Jia P, Chen Y, Li Y, Wang T. Resveratrol and its derivative pterostilbene attenuate oxidative stress-induced intestinal injury by improving mitochondrial redox homeostasis and function via SIRT1 signaling. Free Radical Biology and Medicine. 2021 Dec 1;177:1-4.
- Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018).
- de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021.
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17.
- Elhassan, Y. S., Kluckova, K., Fletcher, R. S., et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Reports. 2019.
- Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916.
- Felici R, Lapucci A, Cavone L, Pratesi S, Berlinguer-Palmini R, Chiarugi A. Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts s. MOLECULAR PHARMACOLOGY. 2015 Jun;87:965-71.
- Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003.
- Imai S, Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes, Obesity and Metabolism. 2013;15(3):26-33.
- Joseph JA, Fisher DR, Bielinski D, Rimando A, Shukitt-Hale B, Michael Barger W, Romeno S, Smith MA, Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Ann N Y Acad Sci. 2004
- Kang, H. T., & Hwang, E. S. Nicotinamide enhances mitochondria quality through autophagy activation in human cells. Aging Cell. 2009.
- Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018.
- Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357.
- McCormack D, McFadden D. A Review of Pterostilbene Antioxidant Activity and Disease Modification.
- Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485.
- Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism. 2016 Dec 13;24(6):795-806.
- Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316.
- Naylor S, Williamson D, Reeve A, Smith MA, Battcher K, Rando TA. A Review of the Effects of Berries and Pterostilbene on Aging and Age-Related Diseases: An Update. Antioxid Redox Signal 2020.
- Pittelli M, Felici R, Pitozzi V, Giovannelli L, Bigagli E, Cialdai F, Romano G, Moroni F, Chiarugi A. Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis. MOLECULAR PHARMACOLOGY. 2011;80(6):1136-46.
- Cerutti, E. Pirinen, C. Lamperti, S. Marchet, Anthony A. Sauve, W. Li, V. Leoni, Eric A. Schon, F. Dantzer, J. Auwerx, C. Viscomi, M. Zeviani, NAD+-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease, Cell. Metab. 19(6) (2014) 1042-1049.
- Rimando AM, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Agric. Food Chem. 2002.
- Samuel Trammell et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948. doi: 10.1038/ncomms12948.
- Sophia E Airhart et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One.2017 Dec 6;12(12):e0186459. doi: 10.1371/journal.pone.0186459.
- Suárez-Rivero, J. M., et al. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases. Front. Pharmacol. 13: 862085. doi: 10.3389/fphar (2022).
- Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K. NAD repletion improves mitochondrial and stem cell function and enhances life span in mice.
- Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients. 2020 Jun;12(6).
- Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87.
- Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78.
- Naylor S, Williamson D, Reeve A, Smith MA, Battcher K, Rando TA. A Review of the Effects of Berries and Pterostilbene on Aging and Age-Related Diseases: An Update. Antioxid Redox Signal 2020.
Product Label Details

Reviews
Customer Rating
5.0 out of 5 star rating.
(19 reviews)
would recommend this product.
- Newest
- Highest Rating
- Lowest Rating
- Oldest
- Most Helpful
Customer Images
服用NAD+後大約一星期,發現睡眠質素改善,酣睡時間增長了,醒來精神較佳。臉部皮膚毛孔明顯收細了,斑紋轉淡。
Response from Customer Service on 12/1/2025
親愛的顧客,感謝您抽出寶貴時間對Prime™ NAD+ 細胞煥新抗老配方發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
頭痛消失術
by Sin
Shop Consultant
on 19/11/2024
一直以來都有20年內的頭痛,每次痛也會一整日,會持續一星期一次頭痛的頻率,或者最少一個月一次頭痛,自從吃了一個月之後,驚訝發現這個現狀改善了很多,後來問我的營養師為何會這樣,他說會對腦部有很大的幫助,除此之外,睡眠質素也改善了很多,神奇的產品。
Response from Customer Service on 19/11/2024
親愛的顧客,感謝您抽出寶貴時間對Prime™ NAD+ 細胞煥新抗老配方發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
性价比高
by LAU
Shop Consultant
on 18/10/2024
前幾年已開始用NMN,由$1600-680不等, 其實看不刭太大分別;自從改用Shop.com的NAD+後,不但省錢并且效果明顯, 面色白透,改善面上泛紅。
Response from Customer Service on 19/10/2024
親愛的顧客,感謝您抽出寶貴時間對Prime™ NAD+ 細胞煥新抗老配方發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
用了臉上紋就變細左.
by Lam
Shop Consultant
on 13/10/2024
用左快4月個
臉上紋就變細左.
Response from Customer Service on 15/10/2024
親愛的顧客,感謝您抽出寶貴時間對Prime™ NAD+ 細胞煥新抗老配方意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
NAD
by Anonymous
on 1/5/2024
產品容易進食,並沒有不良反應,巧効需時
Response from Customer Service on 2/5/2024
親愛的顧客,感謝您抽出寶貴時間對Prime™ NAD+ 細胞煥新抗老配方發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
Share this page!
Copy this link and paste to your favorite social, blog or website.
Link copied! Please paste and share on your favorite platforms.
There was an error copying to your clipboard. Please try again later.