Formulated as the best antioxidant
Validated by research
20x
stronger than vitamin C
50x
stronger than vitamin E
95%
nutrient delivery
Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body.

The Super Antioxidant in OPC-3: Pycnogenol®
Isotonix OPC-3 Powder Drink contains the only isotonic form of Pycnogenol® in the world. Pycnogenol® is a natural plant extract from the bark of French maritime pine tree and the most clinically researched and potent bioflavonoid.

Product Classification

Gluten-Free

Non-GMO

Vegan

Isotonic

Good Manufacturing Practices
How to Take for Maximum Absorption

(1) Pour 1 small capful (3.3 g) of Isotonix powder into a cup.

(2) Add 60 ml of water for each capful and mix.

(3) Enjoy one to three servings a day. For maximum absorption, take Isotonix powder drink on an empty stomach.
Key Ingredients & Benefits

Pine Bark Extract (Pycnogenol®)
A natural plant extract from the bark of the maritime pine tree
One of the most potent natural scavengers of free radicals
Helps maintain healthy circulation and cell vitality

Grape Seed Extract
Typically from red grapes, instead of white grapes
Has a high content of compounds known as oligomeric proanthocyanidins (OPCs)
Helps protect cells from free-radical damage
Promotes cardiovascular health and vision health

Red Wine Extract
High in antioxidant properties
A free radical scavenger
May help maintain healthy circulation

Bilberry Extract
Derived from the fruit of a common European shrub closely related to the blueberry
Extracts of the ripe fruit contain flavonoid pigments known as anthocyanins
May help to support healthy vision and veins
Strengthens capillaries and arteries

Citrus Bioflavonoid Complex
Acts as a light filter protecting the delicate DNA chains by absorbing ultraviolet radiation
One of the World's Most Powerful Antioxidant
Isotonix OPC-3 Powder Drink is an isotonic-capable dietary supplement that is made from a combination of grape seed, red wine and pine bark extracts. Isotonic supplements bear chemical resemblance to your own tears and plasma, so your body absorbs the nutrients rapidly and more effectively.
Isotonix Liquid vs. Standard Tablet & Capsule

0.05 minutes
Isotonic Liquid:
- Rapidly aborsbed by the body
- Enhanced nutriton absorption through osmotic pressure
- Free from artificial colors or flavors
- No binders or fillers to impede nutrion release
- Maximum results

0:40 minutes
Standard Tablet & Capsule:
- Difficult to swallow
- Slowly absorbed by the body
- Reduced absorption of vitamins & minerals
- Binders and fillers impede nutrient release
- Often contains artificial colors or flavors
Frequently Asked Questions
What is Isotonix OPC-3 Powder Drink?
Isotonix OPC-3 Powder Drink is an isotonic-capable dietary supplement that is made from a combination of grape seed, red wine and pine bark extracts. Isotonic supplements bear chemical resemblance to your own tears and plasma, so your body absorbs the nutrients rapidly and more effectively.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. These compounds are chemically related, yet their chemistry differs from one plant to another. This is obvious from the different colors of fruits and plants, which result from the specific bioflavonoid species they contain. A rapidly increasing number of clinical studies show how bioflavonoids support human health and vascular integrity.
What sets Isotonix OPC-3 Powder Drink apart from other bioflavonoid products?
Isotonix OPC-3 Powder Drink offers scientifically proven OPC that support health. This science-driven selection, coupled with the Isotonix delivery system enables this product to be effectively and efficiently absorbed.
Can you take Isotonix OPC-3 Powder Drink in soda, juice, coffee, etc., rather than water?
It is possible but not recommended. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 60ml water per capful. To mix the products with anything else slows down the delivery time and may also affect the percentage of uptake.
Does Isotonix OPC-3 Powder Drink have visible benefits?
It is great to take care of your well being, but ultimately we wish other people to notice we are in great shape! As OPCs support collagen production in the skin, an increase of smoothness and elasticity is the natural consequence. Such an effect was indeed objectively measured in women aged 40 years and older. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. It is compulsory to continuously take Isotonix OPC-3 Powder Drink to keep skin cells at their peak vitality. On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood micro-circulation, which helps detoxify the skin and improves the nutrient supply.
Does this product have “No Detectable GMOs”?
This product is tested with no GMO detected. This product’s raw material may contain genetically modified materials/ingredients, but the finished product does not contain any transgenic DNA fragment or transgenic proteins.
Is Isotonix OPC-3 Powder Drink safe?
Isotonix OPC-3 Powder Drink is safe and free of harmful agents. The product is made in the United States in FDA-inspected facilities using Good Manufacturing Practices. Customers can have confidence in the quality and safety of this product.
Research Scope
- Araghi-Niknam M, et al.. Pine bark extract reduces platelet aggregation. Integr. Med. 2000 Mar 21;2(2):73-77
- Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
- Bertelli AA, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61–3.
- Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
- Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen Pharmacol 1996;27:363–6.
- Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
- Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
- Devaraj, S., et al. Supplementation with a pine barks extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fine, A. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
- Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
- Huynh HT, Teel RW. Effects of pycnogenol on the microsomal metabolism of the tobacco-specific nitrosamine NNK as a function of age. Cancer Lett. 1998; 132:135-139.
- Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218–20.
- Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
- Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
- Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
- Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
- Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
- Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Miztuani K, et al. Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol (Tokyo). 1999 Jan;45 (1):95-106.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Murias, M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
- Nuttall SL, et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Pace-Asciak CR, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163–82.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Petri G, et al. Spectrophotometric and chromatographic investigation of bilberry anthocyanins for qualification purposes. Acta Pharm Hung. 1994 Jul;64(4):117-22.
- Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
- Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
- Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
- Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
- Sato M, et al. Cardioprotective effects of grape seed proanthocyanidins against ischemic reperfusion injury. J Mol Cell Cardiol. 1999; 31:1289-1297
- Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
- Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
- Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
- Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
- Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
- Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
- Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
- Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
Product Label Details
*Pycnogenol® is registered trademark of Horphag Reaserch, Ltd. Use of this product may be protected by one or more U.S patents and other international patents.
This product is not intended to diagnose, treat, cure or prevent any disease.

Reviews
Customer Rating
4.7 out of 5 star rating.
(183 reviews)
would recommend this product.
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Customer Images
Anyone who is breathing must drink OPC3! The best antioxidant I've ever tried. Tastes great and it works!
Let't OPC3!
SUPER ANTIOXIDANT!!!!
by BerthaS
Shop Consultant
on 1/11/2024
Saya tidak pernah lupa untuk memulai pagi saya dengan OPC3. Memberikan saya energi dan daya tahan tubuh pun meningkat. Kulit juga terlihat lebih sehat dan cerah. Rasanya juga enak. Saya suka mencampurkan 2 tutup OPC3 dengan 2 tutup B Complex untuk konsumsi harian saya. LOVE... LOVE... LOVE...
Powerful & Tasty Anti-oxidant
by Anonymous
on 4/10/2024
My most favourite & a powerful anti-oxidant from Isotonix series, which I’ve been taking for 6 years every morning. Love it~
Response from Customer Service on 7/10/2024
Dear Valued Customer,
Thank you for taking the time to leave your thoughts on Isotonix OPC-3® Powder Drink. Thank you again for your support to Market America.
UnFranchsie Services Department
已經使用7年
by Tang
Shop Consultant
on 4/10/2024
好喝!萬能抗氧化沖飲
Response from Customer Service on 7/10/2024
親愛的顧客,感謝您抽出寶貴時間對Isotonix OPC-3®沖飲 發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
不能沒有它
by Tse
Shop Consultant
on 4/10/2024
以前我的經期非常亂,4個月才來一次月經,非常恐怖。睇醫生叫我食一年的藥,我真的不想食藥。當我苦惱的時候就接觸到opc,起初諗住只是試試,食了一個月後,竟然月經回復正常,直到現在,真的好驚訝。除此之外,皮膚還越來越靚,所以每一日不能沒有它。味道超好飲的一杯果汁。
Response from Customer Service on 7/10/2024
親愛的顧客,感謝您抽出寶貴時間對Isotonix OPC-3®沖飲 發表意見。我們很高興您對產品感到滿意。再次感謝閣下對美安的支持!
超連鎖店主服務部 謹啟
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