• Promotes cleansing of the body
• Maximize benefits from GoTrim Weight Loss Solution
• Helps maintain digestive health
• May help suppress appetite by promoting satiety 
• May support liver health
  
  

Gluten Free - the finished product contains no detectable gluten.*

* USA FDA classifies gluten-free as a finished product containing less than 20PPM gluten.

The GoTrim Detox Kit combines five of our most popular products to support your health, wellness and weight loss. Shed and cleanse your body waste and toxin with the GoTrim Detox Kit and save over 10%.

NutriClean® Advanced Fiber Powder comes in a delicious berry flavor and mixes easily with water. It is a blend of soluble fiber, probiotics, restorative probiotics and essential intestinal nutrients. The bowel is the major point of excretion from the digestive system and a major point of excretion from the digestive system and a major determinant in overall digestive system health. This blend of fibers and probiotics team up to maintain digestive tract health as it simultaneously helps to reduce lactose intolerance. So, not only does NutriClean Advanced Fiber Powder deliver top quality soluble fiber, it also provides the beneficial probiotics, which actually work to support and maintain your intestine tract’s number of good bacteria, keeping things in balance in terms of microorganisms.

The kit also paired with our all-star antioxidant, Isotonix OPC-3® Powder Drink, which also helps fight free radicals. Studies have shown OPCs to be more effective than vitamins C and E in neutralizing harmful free radicals and oxidants built up in the body. Thanks to the power of Pycnogenol®, Isotonix OPC-3 Powder Drink helps fight oxidation and free radicals in the gut.

While following a detoxification plan, it’s a good idea to take a multivitamin to supplement your body with essential nutrients. Containing the essential vitamins and minerals, the Isotonix Multivitamin Powder Drink helps promote the conversion of food into energy, maintains normal metabolic functioning, promotes healthy growth and repair of tissues and helps maintain water and electrolyte balance in the body to help promote healthy weight.

To help you manage your cravings while detoxing, GoTrim CORE Fat & Carb Inhibitor helps inhibit the amount of starchy carbohydrates being absorbed by the body while promoting the feeling of fullness to help you manage hunger and cravings that could interfere with the detox cleanse.

Curcumin Extreme is a scientifically supported nutritional supplement formulated to support liver and cognitive health by helping maintain healthy glutathione levels, cell health and integrity and providing antioxidant support. Glutathione is the master antioxidant in the human body which serves to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. Furthermore, glutathione recycles vitamins C and E, also powerful antioxidants, which allows Curcumin Extreme to help maintain these key activities in the body.

GoTrim CORE Fat & Crab Inhibitor

Chromium
Dietary chromium is essential trace mineral assisting the metabolism and use of carbohydrates and fat. Known as the glucose tolerance factor, chromium promotes the delivery of blood sugar to cells, thereby helping to maintain normal insulin activity. Chromium also helps maintain healthy levels of cholesterol and other blood lipids. Due to the role it plays in metabolism, chromium is commonly added to natural weight-loss products.

Phaseolus vulgaris (White Kidney Bean Extract)
Research has shown that supplementation with white kidney bean extract promoted a greater reduction in body weight, body mass index (BMI) and fat mass. Scientifically known as Phaseolus vulgaris, white kidney bean is classified as an amylase inhibitor. Amylase is an enzyme that breaks down starchy carbohydrates into more easily absorbed sugars such as glucose. As individuals age, the ability to use carbohydrates from the diet slows down, causing increased glucose in the blood stream leading to excess storage in the form of fat. Amylase plays a role in the digestion of carbohydrates and subsequently in the absorption of unwanted calories. Supplementation with white kidney bean extract allows certain carbohydrates to pass through the body undigested, stopping them from eventually being converted into fat.

LeptiCore™*
LeptiCore – a proprietary, safe and natural complex of plant-based polysaccharides and esterified fatty acids – has demonstrated the ability to to support a healthy body weight. LeptiCore provides a blend of gum Arabic (Acacia arabica), guar gum (Cyamopsis tetragonoloba), locust bean gum (Ceratonia siliqua), pomegranate (Punica granatum) extract, blue-green algae (Aphanizomenon flos-aquae) extract and beta-carotene.
*Lepticore™ is a trademark of Gateway Health Alliance, Inc.

GreenSelect™ Phytosome™** Green Tea Decaffeinated Extract
GreenSelect Phytosome is unlike the regular green teas you see on the market today. It is a combination of standardized decaffeinated green tea extract and soy phospholipids (lipids that are composed mainly of fatty acids, a phosphate group, and a simple organic molecule). It is designed to help protect the body from the negative effects of free radicals and enhance the product’s bioavailability and efficacy.

Green tea has long been studied for its powerful antioxidant properties. It is also believed to promote a healthy metabolic rate which can help to support a healthy weight. Scientific research has also demonstrated that standardized green tea extracts promote fat oxidation, or the breakdown of stored fat for energy.

**GreenSelect™Phytosome™is a trademark of Indena S.p.A.

CURCUMIN EXTREME

Curcumin (BCM-95™***)
Scientists have long been aware of the wide array of health benefits from the Indian spice turmeric, which is a source of the active phytochemical curcumin. Until now, curcumin has been known to have poor bioavailability, requiring high doses to promote health. BCM-95™ delivers a more bioavailable curcumin for a variety of health benefits.

How is this possible? Traditional 95% extract focuses strictly on one part of the turmeric rhizome. This bioactive substance of turmeric (Curcuma longa) contains “Curcuminoids” and Curcumin is the most important molecule. Research has shown its tremendous health benefit. BCM-95® represents the natural spectrum of turmeric rhizome. It is 100% natural.

Antioxidants have received increased attention, and it’s important to know what nutrients are antioxidants, and information about them. One such nutrient is Curcumin.

The cognitive health supporting of curcumin are among the most studied. These studies show that curcumin can cross the blood-brain barrier and support the normal production of amyloid-beta protein in the brain. This supports cognitive health as we age. Another property of curcumin is its ability to promote normal levels of glutathione, superoxide dismutase and catalase in the brain.

***BCM-95™ 為Dolcas Biotech LLC. 的商標

Broccoli Seed Extract (6% Sulphoraphanes)
The health benefits and protective properties of broccoli and other cruciferous vegetables have been well documented over the past 25 years. Broccoli Seed Extract is a potent source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of enzymes including glutathione synthase. Sulforaphanes promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant.

Sulphoraphanes work to support the body’s natural defense systems and maintain healthy levels of glutathione. Glutathione is the master antioxidant of the body. It is an important molecule that acts as a powerful antioxidant to protect the brain and other body tissues from free radicals. It also acts to recycle vitamin C and E which also neutralize free radicals.

Selenium (Selenomethionine)
Selenium is a required cofactor for selenoproteins such as glutathione peroxidase.

Isotonix OPC-3 Powder Drink

Grape Seed Extract
Grape seed extract are seeds typically from red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). The OPCs are also present in a wide variety of fruits and vegetables, including pine bark (Pycnogenol®) and green tea, where, like grape seed extract, they possess antioxidant properties. These antioxidants help protect cells from free-radical damage, and promote cardiovascular health and vision health. Grape seed extract is extremely rich in polyphenols, a compound that’s high in antioxidants.

Red Wine Extract
Red wine is a naturally occurring antioxidant. It occurs naturally in grape vines, roots, seeds and stalks, with its highest concentration in the skins. Red wine is significantly higher in antioxidant properties than in white wine. This brings up the concept of the French-paradox. In the late 1990s, scientists took note of a phenomenon among the French. There were and still are very high rates of heart health in the provinces where residents ate higher fat foods and drank red wine. The protective properties of red wine are believed to have protected the health of the heart. In test tube and animal studies, red wine extract helped blood vessels remain open and flexible.

Pine Bark Extract (Pycnogenol®†)
Pycnogenol® is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of Pycnogenol®. The extract has three basic properties — it’s a powerful antioxidant, it selectively binds to collagen and elastin, and it aids in the production of endothelial nitric oxide which promotes healthy vasodilation of blood vessels.

As one of the most potent natural scavengers of free radicals, Pycnogenol® mops-up all kinds of aggressive radicals before they cause any damage via oxidative stress. Its antioxidant capabilities also appear to help strengthen blood vessel walls and capillaries. It helps maintain healthy circulation and cell vitality.

Today, Pycnogenol® is one of the most researched ingredients in the natural product marketplace.

†Pycnogenol® is registered trademark of Horphag Research, Ltd. Use of this product may be protected by one or more U.S patents and other international patents.

Bilberry Extract
Bilberry extract is derived from the fruit of a common European shrub closely related to the blueberry.

Extracts of the ripe fruit are known to contain flavonoid pigments known as anthocyanins. These pigments act as antioxidants. Scientific studies have shown that bilberry may help to support healthy vision and veins. Bilberry extract also appears to strengthen capillaries and arteries.

Citrus Bioflavonoid Complex
Bioflavonoids are found in certain plants and act as light filters protecting the delicate DNA chains and other important macromolecules of the plant by absorbing ultraviolet radiation.

Isotonix Multivitamin Powder Drink

Vitamin A (Beta-Carotene)
Vitamin A is a fat-soluble vitamin that is needed by all body tissues for growth and repair. It is part of a group of compounds that include retinol, retinal and beta-carotene. Beta-carotene, also known as pro-vitamin A, is transformed by the body into vitamin A. Vitamin A can be found in foods like organ meats (liver and kidney), egg yolks, butter, milk and cod liver oil. Vitamin A improves the eye's sensitivity to light and maintains eyesight in low light conditions. It supports the normal function of the epithelial tissue, and helps keep skin and mucous membranes healthy. Vitamin A also helps with the growth and development of teeth and bones.

Calcium
Calcium is found in the highest concentrations in milk. Other foods rich in calcium include the vegetables collard greens, Chinese cabbage, mustard greens, broccoli and bok choy, as well as tofu and sardines with bones included.

Calcium is an essential mineral with a wide range of biological roles. Calcium exists in bone primarily in the form of hydroxyapatite (Ca10 (PO4)6 (OH) 2). Hydroxyapatite comprises approximately 40 percent of the weight of bone. The skeleton has an obvious structural requisite for calcium. The skeleton also acts as a storehouse for calcium. Apart from being a major constituent of bones and teeth, calcium is crucial for muscle contraction, nerve conduction, cardiovascular health, blood coagulation, glandular secretion, the production of energy and the maintenance of immune function, among other things.

Calcium is essential for healthy bones and teeth. A sufficient daily calcium intake is necessary for maintaining bone density. The amount of calcium in the blood is regulated by PTH (parathyroid hormone). Low levels of calcium have been associated with reduced bone mass and osteoporosis.

Magnesium
Foods rich in magnesium include unpolished grains, nuts and green vegetables. Green leafy vegetables are potent sources of magnesium because of their chlorophyll content. Meats, starches and milk are less rich sources of magnesium. Refined and processed foods are generally quite low in magnesium. Some surveys report lower intakes, and some believe that the dietary intake for many may be inadequate.

Magnesium is a component of the mineralized part of bone and is necessary for the metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus and calcium. It’s also important for the mobilization of calcium, transporting it inside the cell for further utilization. It supports the normal function of heart, muscles and nerves, together with sodium, potassium and calcium.

Manganese
Manganese is a mineral found in large quantities in both plant and animal matter. The most valuable dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. Manganese is concentrated in the bran of grains, which is removed during processing. Only trace amounts of this element can be found in human tissue. Manganese is predominantly stored in the bones, liver, kidney, and pancreas. Manganese is a component of the antioxidant enzyme manganese superoxide dismutase (MnSOD).

Vitamin C (Ascorbic Acid)
The best food sources of vitamin C include all citrus fruits (oranges, grapefruit, lemons, tangerines), as well as other fruits and vegetables, such as strawberries, tomatoes, broccoli, Brussels sprouts, peppers and cantaloupe. Vitamin C is a rather fragile vitamin, and can be easily destroyed by cooking or exposure of food to oxygen.

Vitamin C promotes a vitamin "sparing" effect, allowing your body to better utilize multiple vitamins and minerals such as thiamin, riboflavin, pantothenic acid, biotin, folic acid, B12, retinaldehyde and alpha-tocopherol and in this case, the mineral calcium. It helps with the formation of collagen. Vitamin C helps maintain the tightness of the cell arrangement. It participates in the oxidation-reduction reaction in the body. It supports the growth of connective tissue, bones and teeth. Vitamin C improves the absorption of iron.

Vitamin C has become the world’s most popular vitamin. One reason is because of its vital role in helping the body fight infections (supporting the immune system). Other vital roles vitamin C plays in the body involve the strengthening of the blood vessels and gums. Although this may sound like a lot, the importance of vitamin C does not stop there.

The most convincing evidence suggesting the need for vitamin C supplementation is based on the fact that humans are incapable of producing vitamin C in their bodies. When studies were conducted on animals to see how much vitamin C they produced in relation to their body weight, it was determined that they produced roughly the equivalent of a human consuming 3,000-7,000 milligrams per day. Since it is water-soluble, vitamin C is flushed from the body each day. Since humans don’t always eat foods containing an adequate amount of vitamin C, it often is beneficial to take a supplement.

Vitamin D3
Regular sunlight exposure is the main way that most humans get their vitamin D. Food sources of vitamin D include vitamin D-fortified milk (100 IU per cup), cod liver oil, and fatty fish, such as salmon, and small amounts are found in egg yolks and liver.
Vitamin D3 helps with the absorption and utilization of calcium and phosphorus. It helps with the growth and development of teeth and bones. It helps maintain normal levels of calcium in the blood. Vitamin D3 also helps to maintain the normal function of nerves and muscles, and helps with calcification of bones.

Vitamin E
Vitamin E is one of the most powerful fat-soluble antioxidants in the body, and it helps protect cell membranes from the damage caused by free radicals. Vitamin E is an antioxidant that is linked to the enhancement of immune system function and topical wound healing. Vitamin E also helps support a healthy cardiovascular system. The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amount of vitamin E and corn and soybean oil contain smaller amounts.

Vitamin E is actually a family of related compounds called tocopherol and tocotrienols. Vitamin E is available in a natural or synthetic form. With vitamin E, the natural form is far more in terms of absorption and retention in the body. The natural form of alpha-tocopherol is known as d-alpha tocopherol, which is what we use in our Heart Health Fish Oil.

Potassium
Foods rich in potassium include fresh vegetables and fruits, such as bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium, in the body, is classified as an electrolyte and is involved in electrical and cellular functions in the body.

Vitamin B12
Vitamin B12 is naturally found in organ meats, liver, beef, pork, eggs, whole milk, cheese, whole wheat bread and fish. Vitamin B12 can only be found in animal products, with small amounts derived from the fermented soy products miso and tempeh, and peanuts. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. Vitamin B12 participates in the metabolism of energy, and helps maintain skin health.

B Vitamins (B1, Nicotinamide, Pantothenate, Biotin)
The B vitamins are largely found in meats, beans, cereals, eggs, nuts, seeds and Brewer’s Yeast. Vitamin B1 participates in the energy metabolism. It helps maintain the proper function of the neuro and cardiovascular systems. Nicotinamide participates in energy metabolism. It also helps maintain healthy skin, neuro and digestive systems. Pantothenate and Biotin participate in the metabolism of energy. They also participate in the formation of fat and cholesterol and aid in the metabolism of amino acids.

Folic Acid
Folic acid is mainly found in fruits and vegetables. Dark leafy greens, oranges, orange juice, beans and peas are the best sources as well as Brewer’s yeast, which supply additional B vitamins. Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid is a component of co-enzymes. It participates in the formation of nucleic acid and nucleic protein. It also helps maintain the normal growth and development of the fetus.

Vitamin B2
Vitamin B2 is a found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a co-enzyme, working with other B vitamins. Vitamin B2 participates in the energy metabolism, and helps maintain skin health.

Vitamin B6
Poultry, fish, whole grains and bananas are the main dietary sources of Vitamin B6. Vitamin B6 is a co-factor required for protein and amino acid metabolism and helps maintain proper fluid balance. It participates in the metabolism of amino acids. It helps with the conversion of tryptophan into Niacin Equivalent. Vitamin B6 helps maintain healthy red blood cells, and neurological system. Vitamin B-6 should be administered as a part of a complex of other B vitamins for best results.

Iodine
Iodine is found in most seafood and in iodized salt. Iodine helps maintain normal growth and development.

Selenium
The best dietary sources of selenium include nuts, unrefined grains, brown rice, wheat germ and seafood.

Copper
An essential trace mineral in human nutrition, copper, is important for a wide range of biochemical processes, which are necessary for the maintenance of good health. Foods that include the richest sources of copper are nuts, seeds, legumes, the bran and germ portions of grains, liver, kidneys, shellfish, oysters and crustaceans. There are experimental indications that suggest that copper supplementation may have some beneficial effects on immunity, for those with copper deficiency.

Chromium
There are claims that Chromium supports weight loss and increases muscle mass. More than 90 percent of American diets do not provide the recommended amount of chromium.

Chromium is found in small amounts in many foods. Food sources of chromium include brewer’s yeast, whole-grain cereals, broccoli, prunes, mushrooms, beer, spices, brown sugar, coffee, tea, wine and meat products.

Zinc
Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafoods, including oysters. It is a component of multiple enzymes and proteins. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. Zinc participates in the formation of nucleic acid and protein. It also participates in the metabolism of energy.

NutriClean Advanced Fiber Powder

L-Glutamine
High-protein foods including meat, fish, beans and dairy products are excellent sources of glutamine. L-glutamine is an amino acid derived from another amino acid, glutamic acid. Glutamine is a restorative amino acid that is used by the GI tract as its source of fuel. Glutamine helps to promoting immune health. Heavy exercise, infection, surgery and trauma can all deplete the body's glutamine reserves, particularly in muscle cells. Because the cells of the intestine use glutamine for fuel, supplemental L-glutamine has been used to promote digestive health.

Inulin Fiber (fructo-oligosaccharide extract of chicory root)
Inulin fiber is a type of prebiotic fiber. Prebiotics are food sources that are preferred by friendly bacteria. Inulin or fructo-oligosaccharides (FOS) are fibers in the form of starches that the human body cannot fully digest. When a person consumes prebiotics, the undigested portions provide nourishment for beneficial bacteria in the digestive tract. Inulins may promote the growth of favorable bacterial populations, such as bifidobacteria in the colon. Bifidobacteria may inhibit the growth of pathogenic bacteria.

Fibersol-2 (soluble fiber flucose polymer complex) 5,000 mg
Fibersol-2 is a type of soluble fiber. It has some positive impact on the elimination of wastes and intestinal cleansing, yet it may assist in s">Probiotic Blend (Lactobacillus acidophilus, Lactobacillus plantarum, Bifodobacterium bifidum, Lactobacillus casei)
Probiotics such as acidophilus, or lactobacillus acidophilus, are certain forms of bacteria that are also known as the "beneficial" or "good" bacteria. These bacteria actually help to maintain a healthy functioning digestive tract. Disruptions to these populations of probiotics (good bacteria) are common and must be kept at adequate levels in order to overwhelm other bacteria, which may begin to run rampant in the event the good bacteria levels decrease.

All in all, the probiotic bacteria tend to result in a heightened ability of the immune system to recognize invading organisms.  Several key fighters of the immune system, including macrophages, immunoglobulins cytokines are benefited by regular intake of beneficial bacteria.

How does a detox work?
During day-to-day processes, your body may grow less able to naturally flush out all its self-produced toxic waste. When toxins are retained and stored in the body the condition is called toxemia. Detox can help purge the blood and tissues from toxic residue, but detox also cleanses and rejuvenates the entire excretory system and clears clogged bowels and blocked lungs. It also flushes out sluggish kidneys and the bladder. With caustic pollutants like ammonia or excessive fatty acids shed from the body, your organ systems can start functioning properly, thus kick starting your metabolism and setting the stage for healthy weight loss.

What else can I do to enhance my results while using the GoTrim Detox Kit?
To enhance the effects of the GoTrim Detox Kit cleanse, you should increase your intake of raw fruits, vegetables. Eat more natural foods and increase your exercise. You should limit caffeinated beverages to one serving or cup of coffee per day. Cleansing tends to boost energy levels. Reduce your protein intake. Protein contains ammonia, which must be filtered by the liver. Limit your intake of eggs and meats (especially red meats) to decrease strain on the liver. Refined sugars and carbs should be avoided, including cookies, crackers and other foods in a bag or box to decrease stimulation of insulin secretion during the cleanse. Also, stay away from artificial sweeteners and MSG, a common additive, and any other ingredients that do not occur naturally in foods to avoid additional stress on the liver. You must eliminate the following things from your lifestyle during the detox cleanse:

Processed foods — such as luncheon meats, boxed meals, white bread and cheese foods

Smoking — cigarettes contain thousands of toxic chemicals. Please refrain from smoking if at all possible.

Soft drinks — phosphoric acid can upset the pH balance in your body in addition to pulling much needed calcium from the bones when consumed in large quantities. Soft drinks can also be high in sugar.

Hydrogenated oils — foods are hydrogenated to increase their s">Who should use the GoTrim Detox Kit?
If you are starting or renewing your weight loss efforts, detox can help promote or “kick start” your metabolism. Especially if you are experiencing a plateau in your weight loss efforts and your activity levels and eating patterns have not changed, starting a detoxification program may be the perfect option for you!

Who should not use the GoTrim Detox Kit?
Consult your physician if you have frequent diarrhea. If you are pregnant, nursing, taking medication or have a medical condition, consult your physician before using this product. Do not use this product if you are experiencing abdominal pain, nausea or vomiting. If you are allergic to any of the ingredients in these products, you should not use the GoTrim Detox Kit.

Are the products in GoTrim Detox Kit safe?
GoTrim Detox Kit is safe and free of harmful agents. These products are made in the United States in FDA inspected facilities using Good Manufacturing Practices. Customers can have confidence in the quality and safety of this product. These products are not intended to diagnose, treat or prevent any disease.

GoTrim CORE

• Anderson, R. Effects of chromium on body composition and weight loss. Nutrition Reviews. 56(9): 266-270, 1998.
• Anderson, R., et al. Chromium supplementation of human subjects: effects on glucose, insulin, and lipid variables. Metabolism. 32(9): 894-899, 1983.
• Blundell, J., et al. Regulation of appetite: role of leptin in signaling systems for drive and satiety. International Journal of Obesity. 25(Supplement 1): 529-534, 2001.
• Bray, G. and York, D. Clinical review 90: Leptin and clinical medicine: a new piece in the puzzle of obesity. Journal of Clinical Endocrinology and Metabolism. 82(9):2771-6, 1997.
• Cakir, B., et al. Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers. Physiology Research. 56: 315-322, 2007.
• Cefalu, W. and Hu, F. Role of chromium in human health and in diabetes. Diabetes Care. 27: 2741- 2751, 2004.
• Celleno, L., et al. A dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. International Journal of Medical Sciences. 4(1):45-52, 2007.
• Cohen P., et al. Selective deletion of leptin receptor in neurons leads to obesity. Journal of Clinical Investigation. 108(8):1113-21, 2001.
• Di Pierro, F., et al. GreenSelect® Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review. 14:154-160, 2009.
• Flegal, K., et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 303(3):235-241, 2010.
• Fox, G. and Sabovic, Z. Chromium picolinate supplementation for diabetes mellitus. The Journal of Family Practice. 46: 83-86, 1998.
• French, S. Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. British Journal of Nutrition. 93(Supplement 1): S23-S26, 2004.
• Friedman, J. The function of leptin in nutrition, weight, and physiology. Nutrition Reviews. 60(10 Pt 2):S1-14; discussion S68-84, 85-7, 2002. Review.
• Kaats, G., et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research. 59(6): 379-387, 1998.
• Kuate, D., et al. The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome. Lipids in Health and Disease. 9: 1-7, 2010.
• Lee, N. and Reasner, C. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care. 17(12): 1449-1452, 1994.
• Martin, J., et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care. 29(8): 1826-1832, 2006.
• Obiro, W., et al. The nutraceutical role of Phaseolus vulgaris alpha-amylase inhibitor. British Journal of Nutrition. 100: 1-12, 2008.
• Pittler, M. and Ernst, E. Dietary supplements for body-weight reduction: a systematic review. American Journal of Clinical Nutrition. 79(4): 529-536, 2004.
• Preuss H. Bean amylase inhibitor and other carbohydrate absorption blockers: effects on diabesity and general health. Journal of the American College of Nutrition. 28(3):266-76, 2009.
• Qi, Y., et al. Adiponectin acts in the brain to decrease body weight. Nature Medicine. 10(5):524-9, 2004.
• Rabinovitz, H., et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. International Journal of Vitamin and Nutrition Research. 74(3):178-82, 2004.
• Sinha, M. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. Journal of Clinical Investigation. 98(6):1277-82, 1996.
• Sparti, A., et al. Effect of diets high or low in unavailable and slowly digestible carbohydrates on the pattern of 24-h substrate oxidation and feeling of hunger in humans. The American Journal of Clinical Nutrition. 73: 1462-1468, 2000.
• TalYeh, G., et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 26(4): 1277-1294, 2003.
• Udani J., et al. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Alternative Medicine Review. 9(1):63-9, 2004.
• Udani, J and Singh B. Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Alternative Therapies in Health and Medicine. 13(4):32-7, 2007.
• Venables, M., et al. Green tea extract ingestion, fat oxidation and glucose tolerance in healthy humans. American Journal of Clinical Nutrition. 87:778-84, 2008.
• Wang, M., et al. Fat storage in adipocytes requires inactivation of leptin’s paracrine activity: implications for treatment of human obesity. Proceedings National Academy of Sciences USA. 102(50):18011-6, 2005.
• Zeman, M., et al. Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. Neuro Endocrinology Letters. 30(3):387-95, 2009.
  
  

CURCUMIN EXTREME

• Araujo, C. and Leon, L. Biological activities of Curcuma longa L. Memorias do Instituto Oswaldo Cruz. 96(5): 723-728, 2001.
• Biswas, S., et al. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants and Redox Signaling. 7(1-2): 32-41, 2005.
• Cheng, Y., et al. Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells. Chinese Medical Journal. 120(9): 794-801, 2007.
• Cornblatt, B., et al. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. 28(7): 1485-1490, 2007.
• Dairam, A., et al. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. Journal of Agricultural and Food Chemistry. 55(3): 1039- 1044, 2007.
• Dickinson, D., et al. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate- cysteine ligase gene expression. FASEB. 17(3): 473-475, 2003.
• Farombi, E., et al. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food and Chemical Toxicology. 46(4): 1279-1287, 2008.
• Funk, J., et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. Journal of Natural Products. 69(3): 351-355, 2006.
• Gao, X. and Talalay, P. Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 101(28): 10446-10451, 2004.
• Garcia-Alloza, M., et al. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102(4): 1095-1104, 2007.
• Jagetia, G. and Aggarwal, B. "Spicing up" of the immune system by curcumin. Journal of Clinical Immunology. 27(1): 19-35, 2007.
• Juge, N., et al. Molecular basis for chemoprevention by sulforaphane: a comprehensive review.Cellular and Molecular Life Sciences. 64(9): 1105-1127, 2007.
• Kaur, G., et al. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clinical and Experimental Immunology. 145(2): 313-321, 2006.
• Kim, G., et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. Journal of Immunology. 174(12): 8116-8124,2005.
• Kurup, V., et al. Immune response modulation by curcumin in a latex allergy model. Clinical and Molecular Allergy. 5: 1, 2007.
• Lim, G., et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience. 21(21): 8370-8377, 2001.
• Lin, J. Molecular targets of curcumin. Advances in Experimental Medicine and Biology. 595:227-243, 2007.
• Magalska, A., et al. Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells. Acta Biochimica Polonica. 53(3): 531-538, 2006.
• Maheshwari, R., et al. Multiple biological activities of curcumin: a short review. Life Sciences.
  78(18): 2081-2087, 2006.
• Mathuria, N. and Verma, R. Ameliorative effect of curcumin on aflatoxin-induced toxicity in
• DNA, RNA and protein in liver and kidney of mice. Acta Poloniae Pharmaceutica. 64(6): 497-
  502, 2007.
• Curcuma longa (turmeric). Alternative Medicine Review. 6(suppl): S62-S66, 2001.
• Morimitsu, Y., et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. Journal of Biological Chemistry. 277(5): 3456-3463, 2002.
• Naik, R., et al. Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice
  culture in vitro. Journal of Ethnopharmacology. 95(1): 31-37, 2004.
• Nanji, A., et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. American Journal of Physiology. 284(2): G321-G327, 2003.
• Ng, T., et al. Curry consumption and cognitive function in the elderly. American Journal of
  164(9): 898-906, 2006.
• Nishinaka, T., et al. Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element. Toxicology Letters. 170(3): 238-247, 2007.
• Noyan-Ashraf, M., et al. Dietary approach to decrease aging-related CNS inflammation.
  Nutritional Neuroscience. 8(2): 101-110, 2005.
• O’Connell, M. and Rushworth, S. Curcumin: potential for hepatic fibrosis therapy? British
  Journal of Pharmacology. 153(3): 403-405, 2007.
• Osawa, T. Nephroprotective and hepatoprotective effects of curcuminoids. Advances in
  Experimental Medicine and Biology. 595: 407-423, 2007.
• Pari, L. and Amali, D. Protective role of tetrahydrocurcumin (THC) an active principle of
  turmeric on chloroquine induced hepatotoxicity in rats. Journal of Pharmacy and Pharmaceutical
  8(1): 115-123, 2005.
• Rushworth, S., et al. Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochemical and Biophysical Research Communications. 341(4): 1007-1016, 2006.
• Salvioli, S., et al. Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evidence-based Complementary and Alternative Medicine. 4(2): 181-190, 2007.
• Scapagnini, G., et al. Curcumin activates defensive genes and protects neurons against
  oxidative stress. Antioxidants and Redox Signaling. 8(3-4): 395-403, 2006.
• Shen, S., et al. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World Journal of Gastroenterology. 13(13): 1953-1961, 2007.
• Shishodia, S., et al. Curcumin: getting back to the roots. Annals of the New York Academy of
  1056: 206-217, 2005.
• Shu, J., et al. The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine. Journal of Chinese Medicinal Materials. 30(11): 1421-1425, 2007.
• Shu, J., et al. Therapeutic effects of curcumin treatment on hepatic fibrosis. Chinese Journal of
  15(10): 753-757, 2007.
• Shukla, P., et al. Protective effect of curcumin against lead neurotoxicity in rat. Human and
  Experimental Toxicology. 22(12): 653-658, 2003.
• Smith, T., et al. Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells. Carcinogenesis. 25(8): 1409-1415, 2004.
• Srinivasan, M., et al. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutation Research. 611(1-2): 96-103,
• Thejass, P. and Kuttan, G. Antimetastatic activity of Sulforaphane. Life Sciences. 78(26): 3043-
  3050, 2006.
• Thejass, P. and Kuttan, G. Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma. Immunopharmacology and Immunotoxicology. 28(3): 443-457, 2006.
• Thejass, P. and Kuttan, G. Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14(7-8): 538-545, 2007.
• Wakabayashi, N., et al. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proceedings ofthe National Academy of Sciences of the United States of America. 101(7): 2040-2045, 2004.
• Wei, Q., et al. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochimica et Biophysica Acta. 1760(1): 70-77, 2006.
• Wu, A., et al. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. 197(2): 309-317, 2006.
• Xu, Y., et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF
  expression and phosphorylation of CREB. Brain Research. 1122(1): 56-64, 2006.
• Yadav, V., et al. Immunomodulatory effects of curcumin. Immunopharmacology and
  27(3): 485-497, 2005.
• Yang, F., et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. Journal of Biological Chemistry. 280(7): 5892-5901, 2005.
• Ye, S., et al. Effect of curcumin on the induction of glutathione S-transferases and
  NADP(H):quinone oxidoreductase and its possible mechanism of action. Acta Pharmaceutica
  42(4): 376-380, 2007.
• Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's
  disease patients. Journal of Alzheimer’s Disease. 10(1): 1-7, 2006.
• Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. American Journal of Physiology. 290(5): G883-G893, 2006.
• Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. American Journal of Physiology. 292(1): G113-G123, 2007.
• Zheng, S., et al. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radical Biology and Medicine. 43(3): 444-453, 2007.
  
  

Isotonix OPC-3 Powder Drink

• Araghi-Niknam M, et al.. Pine bark extract reduces platelet aggregation. Integr. Med. 2000 Mar 21;2(2):73-77
• Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
• Bertelli AA, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res1996;22:61–3.
• Blazsó, G., et al. Anti-inflammatory and superoxide radical scavengingactivities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
• Chen CK, Pace-Asciak CR. Vasorelaxing activity of resveratrol and quercetinin isolated rat aorta. Gen Pharmacol 1996;27:363–6.
• Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinusmaritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
• Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
• Devaraj, S., et al. Supplementation with a pine barks extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
• Fine, A. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
• Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
• Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001.
• Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
• Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
• Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
• Liu, X., et al. French maritime pine bark extract pycnogenol dosedependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
• Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
• Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
• Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
• Miztuani K, et al. Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol (Tokyo). 1999 Jan;45 (1):95-106.
• Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Murias, M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
• Nuttall SL, et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Pace-Asciak CR, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163–82.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidinrich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Petri G, et al. Spectrophotometric and chromatographic investigation of bilberry anthocyanins for qualification purposes. Acta Pharm Hung. 1994 Jul;64(4):117-22.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
• Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
• Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
• Sato M, et al. Cardioprotective effects of grape seed proanthocyanidins against ischemic reperfusion injury. J Mol Cell Cardiol. 1999; 31:1289-1297
• Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
• Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
• Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
• Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
• Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
• Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
• Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
• Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
• Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
  
  

NutriClean Advanced Fiber Powder
(Fibersol-2)

• Satouchi M et al, "Effects of indigestible dextrin on bowel movements," Japanese J Nutr, 51:31-37, 1993.
• Tokunaga K and Matsuoka A, "Effects of a [FOSHU] which contains indigestible dextrin as an effective ingredient on glucose and lipid metabolism," J Japanese Diabetes Society, 42:61-65, 1999.
• Wakabayashi S et al, "Effects of indigestible dextrin on glucose tolerance in rats," J Endocrinology, 144:533-538, 1995.
• Watanabe O et al, "Effects of galacto-oligosaccharide and indigestible dextrin on fat accumulation in broiler," Japanese Poultry Science, 30:35, 1993.

(Inulin)

• Brighenti F, Casiraghi MC, Canzi E, Ferrari A. Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers. Eur J Clin Nutr. 1999; 53:726-733.
• Cummings JH, Christie S, Cole TJ. A study of fructo oligosaccharides in the prevention of travellers' diarrhoea. Aliment Pharmacol Ther. 2001;15:1139–1145.
• Davidson MH, Synecki C, Maki KC, Drennen KB. Effects of dietary inulin in serum lipids in men and women with hypercholesterolaemia. Nutr Res. 1998;3:503–17.
• Ducros V, Arnaud J, Tahiri M, et al. Influence of short-chain fructo-oligosaccharides (sc-FOS) on absorption of Cu, Zn, and Se in healthy postmenopausal women. J Am Coll Nutr. 2005;24:30–7.
• Giacco R, Clemente G, Luongo D, et al. Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals. Clin Nutr. 2004;23:331–40.
• Jackson KG, Taylor GRJ, Clohessy AM, Williams CM. The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr. 1999;82:23–30.
• Menne E, Guggenbuhl N, Roberfroid M. Fn-type chicory inulin hydrolysate has a prebiotic effect in humans. J Nutr. 2000; 130:1197-1199.
• Olesen M, Gudmand-Hoyer E. Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome. Am J Clin Nutr. 2000;72:1570–5.
• Pedersen A, Sandstrom B, van Amelsvoort JMM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr. 1997;78:215–22.
• Reddy BS, Hamid R, Rao CV. Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis. 1997; 18:1371-1374.
• Roberfroid MB, Delzenne NM. Dietary fructans. Annu Rev Nutr. 1998; 18:117-143.
• Roberfroid MB, Van Loo JA, Gibson GR. The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr. 1998; 128:11-19.
• Schaafsma G, Meuling WJ, van Dokkum W, Bouley C. Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr. 1998;52:436–40.
• Tahiri M, Tressol JC, Arnaud J, et al. Effect of short-chain fructooligosaccharides on intestinal calcium absorption and calcium status in postmenopausal women: a stable-isotope study. Am J Clin Nutr. 2003;77:449–457.
• Tahiri M, Tressol JC, Arnaud J, et al. Five-week intake of short-chain fructo-oligosaccharides increases intestinal absorption and status of magnesium in postmenopausal women. J Bone Miner Res. 2001;16:2152–2160.
• van Dokkum W, Wezendonk B, Srikumar TS, van den Heuvel EG. Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr. 99;53:1–7.
• Waligora-Dupriet AJ, Campeotto F, Nicolis I et al. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. Int J Food Microbiol. 2006 Sep 20 [Epub ahead of print]
• Williams CM. Effects of inulin on lipid parameters in humans. J Nutr. 1999; 129(7 Suppl):1471S-1473S.
• Williams CM, Jackson KG. Inulin and oligofructose: effects on lipid metabolism from human studies. Br J Nutr. 2002;87(suppl 2):S261–4.

(L-Glutamine)

• Akobeng AK, Miller V, Stanton J, et al. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease. J Pediatr Gastroenterol Nutr. 2000;30:78–84.
• Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr.1990;14(suppl 4):109S–113S.
• Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut. 2001;48:28–33.
• Den Hond E, Hiele M, Peeters M, et al. Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's disease. JPEN J Parenter Enteral Nutr. 1999;23:7–11.
• Fox AD, Kripke SA, Berman JR, et al. Reduction of the severity of enterocolitis by glutamine-supplemented enteral diets. Surg Forum. 1987;38:43–44.
• Fujita T, Sakurai K. Efficacy of glutamine-enriched enteral nutrition in an experimental model of mucosal ulcerative colitis. Br J Surg. 1995;82:749–751.
• Garcia-de-Lorenzo A, Zarazaga A, Garcia-Luna PP, et al. Clinical evidence for enteral nutritional support with glutamine: a systematic review. Nutrition. 2003;19:805-11.
• Huffman FG, Walgren ME. L-Glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV Clin Trials. 2003;4:324-9. gut integrity. Lancet. 1993;341:1363–1365.
• Shabert JK, Winslow C, Lacey JM, et al. Glutamine-antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomized, double-blind controlled trial. Nutrition. 1999;15:860–864.
• van der Hulst RR, van Kreel BK, von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. 1993 May 29;341(8857):1363-5.
• Yang C, Li N, Li JS. Effect of glutamine on change in early postoperative intestinal permeability and its relation to systemic inflammatory response. World J Gastroenterol. 2004;10:1992-4.
• Zoli G, Care M, Falco F, et al. Effect of oral glutamine on intestinal permeability and nutritional status in Crohn's disease [abstract]. Gastroenterology. 1995;108:A766.

(Probiotic Blend)

• Agerholm-Larsen L, Raben A, Haulrik N, Hansen AS, Manders M, Astrup A. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr. 2000 Apr;54(4):288-97.
• Arunachalam K, Gill HS, Chandra RK. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr. 2000 Mar;54(3):263-7.
• Barone C, Pettinato R, Avola E, Alberti A, Greco D, Failla P, Romano C. Comparison of three probiotics in the treatment of acute diarrhea in mentally retarded children. Minerva Pediatr. 2000 Mar;52(3):161-5.
• Bengmark S. Bacteria for optimal health. Nutrition. 2000 Jul-Aug;16(7-8):611-5.
• Bengmark S. Colonic food: pre- and probiotics. Am J Gastroenterol. 2000 Jan;95(1 Suppl):S5-7.
• Bengmark S. Ecological control of the gastrointestinal tract. The role of probiotic flora. Gut. 1998 Jan;42(1):2-7.
• Biancone L, Pallone F. Current treatment modalities in active Crohn's disease. Ital J Gastroenterol Hepatol. 1999 Aug-Sep;31(6):508-14.
• Caplan MS, Jilling T. Neonatal necrotizing enterocolitis: possible role of probiotic supplementation. J Pediatr Gastroenterol Nutr. 2000;30 Suppl 2:S18-22.
• Cerrato PL. Can "healthy" bacteria ward off disease? RN. 2000 Apr;63(4):71-4.
• Chin J, Turner B, Barchia I, Mullbacher A. Immune response to orally consumed antigens and probiotic bacteria. Immunol Cell Biol. 2000 Feb;78(1):55-66.
• Collins MD, Gibson GR. Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr. 1999 May;69(5):1052S-1057S.
• Cunningham-Rundles S, Ahrne S, Bengmark S, Johann-Liang R, Marshall F, Metakis L, Califano C, Dunn AM, Grassey C, Hinds G, Cervia J. Probiotics and immune response. Am J Gastroenterol. 2000 Jan;95(1 Suppl):S22-5.
• Davidson GP, Butler RN. Probiotics in pediatric gastrointestinal disorders. Curr Opin Pediatr. 2000 Oct;12(5):477-81.
• de Roos NM, Katan MB. Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998. Am J Clin Nutr. 2000 Feb;71(2):405-11.
• Dugas B, Mercenier A, Lenoir-Wijnkoop I, Arnaud C, Dugas N, Postaire E. Immunity and probiotics. Immunol Today. 1999 Sep;20(9):387-90.
• Dunne C, Murphy L, Flynn S, O'Mahony L, O'Halloran S, Feeney M, Morrissey D, Thornton G, Fitzgerald G, Daly C, Kiely B, Quigley EM, O'Sullivan GC, Shanahan F, Collins JK. Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Antonie Van Leeuwenhoek. 1999 Jul-Nov;76(1-4):279-92.
• Dupont C. Bacterial flora in the infant and intestinal immunity: Implication and prospects for infant food with probiotics. Arch Pediatr. 2000 May;7 Suppl 2:252s-255s.
• Erickson KL, Hubbard NE. Probiotic immunomodulation in health and disease. J Nutr. 2000 Feb;130(2S Suppl):403S-409S.
• Folwaczny C. Probiotics for prevention of ulcerative colitis recurrence: alternative medicine added to standard treatment? Z Gastroenterol. 2000 Jun;38(6):547-50.
• Friedrich MJ. A bit of culture for children: probiotics may improve health and fight disease. JAMA. 2000 Sep 20;284(11):1365-6.
• Gibson GR, Fuller R. Aspects of in vitro and in vivo research approaches directed toward identifying probiotics and prebiotics for human use. J Nutr. 2000 Feb;130(2S Suppl):391S-395S.
• Gibson GR, McCartney AL. Modification of the gut flora by dietary means. Biochem Soc Trans. 1998 May;26(2):222-8.
• Gismondo MR, Drago L, Lombardi A. Review of probiotics available to modify gastrointestinal flora. Int J Antimicrob Agents. 1999 Aug;12(4):287-92.
• Goldin BR. Health benefits of probiotics. Br J Nutr. 1998 Oct;80(4):S203-7.
• Gomez-Gil B, Roque A, Turnbull JF, Inglis V. A review on the use of microorganisms as probiotics. Rev Latinoam Microbiol. 1998 Jul-Dec;40(3-4):166-72.
• Gorbach SL. Probiotics and gastrointestinal health. Am J Gastroenterol. 2000 Jan;95(1 Suppl):S2-4.
• Guslandi M. The relationship between gut microflora and intestinal inflammation. Can J Gastroenterol. 2000 Jan;14(1):32.
• Heyman M. Effect of lactic acid bacteria on diarrheal diseases. J Am Coll Nutr. 2000 Apr;19(2 Suppl):137S-146S.
• Hoerr RA, Bostwick EF. Bioactive proteins and probiotic bacteria: modulators of nutritional health. Nutrition. 2000 Jul-Aug;16(7-8):711-3.
• Holzapfel WH, Haberer P, Snel J, Schillinger U, Huis in't Veld JH. Overview of gut flora and probiotics. Int J Food Microbiol. 1998 May 26;41(2):85-101.
• Hove H, Norgaard H, Mortensen PB. Lactic acid bacteria and the human gastrointestinal tract. Eur J Clin Nutr. 1999 May;53(5):339-50.
• Hoyos AB. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis. 1999 Summer;3(4):197-202.
• Isolauri E. The use of probiotics in paediatrics. Hosp Med. 2000 Jan;61(1):6-7.
• Kasper H. Protection against gastrointestinal diseases--present facts and future developments. Int J Food Microbiol. 1998 May 26;41(2):127-31.
• Kirjavainen PV, Apostolou E, Salminen SJ, Isolauri E. New aspects of probiotics--a novel approach in the management of food allergy. Allergy. 1999 Sep;54(9):909-15.
• Klaenhammer TR. Probiotic bacteria: today and tomorrow. J Nutr. 2000 Feb;130(2S Suppl):415S-416S. 40. Kochhar KP. Probiotics and gastrointestinal function in health and disease. Trop Gastroenterol. 2000 Jan-Mar;21(1):8-11.
• LaMont JT. The renaissance of probiotics and prebiotics. Gastroenterology. 2000 Aug;119(2):291.
• Levy J. Immunonutrition: the pediatric experience. Nutrition. 1998 Jul-Aug;14(7-8):641-7. 43. Macfarlane GT, Cummings JH. Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health? BMJ. 1999 Apr 10;318(7189):999-1003.
• Matsuzaki T, Chin J. Modulating immune responses with probiotic bacteria. Immunol Cell Biol. 2000 Feb;78(1):67-73.
• Orrhage K, Nord CE. Bifidobacteria and lactobacilli in human health. Drugs Exp Clin Res. 2000;26(3):95-111.
• Ouwehand AC, Isolauri E, Kirjavainen PV, Tolkko S, Salminen SJ. The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus. Lett Appl Microbiol. 2000 Jan;30(1):10-3.
• Reid G. The scientific basis for probiotic strains of Lactobacillus. Appl Environ Microbiol. 1999 Sep;65(9):3763-6.
• Roberfroid MB. Prebiotics and probiotics: are they functional foods? Am J Clin Nutr. 2000 Jun;71(6 Suppl):1682S-7S; discussion 1688S-90S.
• Rolfe RD. The role of probiotic cultures in the control of gastrointestinal health. J Nutr. 2000 Feb;130(2S Suppl):396S-402S.
• Saavedra JM. Probiotics plus antibiotics: regulating our bacterial environment. J Pediatr. 1999 Nov;135(5):535-7.
• Sanders ME. Considerations for use of probiotic bacteria to modulate human health. J Nutr. 2000 Feb;130(2S Suppl):384S-390S.
• Shanahan F. Immunology. Therapeutic manipulation of gut flora. Science. 2000 Aug 25;289(5483):1311-2.
• Shanahan F. Probiotics and inflammatory bowel disease: is there a scientific rationale? Inflamm Bowel Dis. 2000 May;6(2):107-15.
• Studd C. Probiotic containing fermented milk supplement may improve the institution of early enteral nutrition. Crit Care Med. 2000 Apr;28(4):1255-6.
• Szilagyi A. Prebiotics or probiotics for lactose intolerance: a question of adaptation. Am J Clin Nutr. 1999 Jul;70(1):105-6.
• Taylor GR, Williams CM. Effects of probiotics and prebiotics on blood lipids. Br J Nutr. 1998 Oct;80(4):S225-30.
• Torrens JK, McWhinney PH. Probiotics and life-threatening infection. J Infect. 1999 Nov;39(3):246.
• Vanderhoof JA, Whitney DB, Antonson DL, Hanner TL, Lupo JV, Young RJ. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. J Pediatr. 1999 Nov;135(5):564-8.
• Vanderhoof JA, Young RJ. Use of probiotics in childhood gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 1998 Sep;27(3):323-32.
• Vanderhoof JA. Probiotics and intestinal inflammatory disorders in infants and children. J Pediatr Gastroenterol Nutr. 2000;30 Suppl 2:S34-8.
• Vilpponen-Salmela T, Alander M, Satokari R, Bjorkman P, Kontula P, Korpela R, Saxelin M, Mattila-Sandholm T, von Wright A. Probiotic bacteria and intestinal health: new methods of investigation. J Physiol Paris. 2000 Mar-Apr;94(2):157-8.
• von Wright A, Salminen S. Probiotics: established effects and open questions. Eur J Gastroenterol Hepatol. 1999 Nov;11(11):1195-8.
• Yasui H, Shida K, Matsuzaki T, Yokokura T. Immunomodulatory function of lactic acid bacteria. Antonie Van Leeuwenhoek. 1999 Jul-Nov;76(1-4):383-9.
• Zhou JS, Shu Q, Rutherfurd KJ, Prasad J, Gopal PK, Gill HS. Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria. Food Chem Toxicol. 2000 Feb-Mar;38(2-3):153-61.