Restore, Rebuild, and Reset with Core 3 Health: three powerful products in three simple steps. Our hottest health superstars have been carefully selected for one triple-threat system for maximum effect and truly amazing results. Feel empowered as Isotonix OPC-3^â Powder Drink, Isotonix^â Activated B-Complex Powder Drink and Prime^™ NAD+ work together to help you wake up refreshed, turn back the clock on aging, fuel your physical performance and support a good night sleep. Experience Core 3 Health’s powerhouse of antioxidants, critical nutrients and cutting-edge science — and finally stay healthy to your core!

• Works synergistically for max results: Our hottest health superstars in one triple-threat system.
• Wake up refreshed: Fill the nutritional gaps and vitamin deficiencies that are zapping your energy, disrupting your sleep and holding you back.
• Turn back the clock: Be a healthier, more youthful you and slow the effects of aging for mental and physical vitality that rivals the Olympians.
• Fuel peak performance: Give your body the supplements it needs for optimally functioning muscles, bones, joints, blood flow, vision and more!
• Save. Share. Earn. We know you’ll love it, so we’re offering bonus perks.

Isotonix OPC-3^® Powder Drink
The world’s most powerful antioxidant with 4X the staying-power of vitamin C for supercharged oxygen delivery, glowing skin, and a surge of vitality!

Isotonix^® Activated B-Complex Powder Drink
Stress-busting, sleep-enhancing, heart-strengthening, and energy-activating for peak performance!

Prime^™ NAD+
Cutting-edge science that renews cells and DNA so you are energized, mentally sharp, and look and feel younger!

Optimized health isn’t just about supplements. It’s about a thoughtful approach to maximizing metabolism, aging with energy and supporting your vitality. It’s also about supporting the body’s natural rhythm.

You’re a symphony of nutrient signals, sleep cues and hormonal cycles, but modern life has us ignore these biological cues, so we’ve fallen out of rhythm — creating disruption in our response to stress, physical and mental demands, food cravings and healthy weight. We need to rebuild from the ground up and recreate a total-body approach to health and longevity. Not all supplements are created equal. You can have the best nutrients, botanicals and amino acids in your wellness supplements, but if those nutrients can’t reach the proper areas of the body and deliver the critical nutrients (concentrated and ready to do the job of healthy metabolism), then you may not get the results you’re seeking. CORE 3 Health offers a 1, 2, 3 regimen with Isotonix OPC-3 Powder Drink, Isotonix Activated B-Complex Powder Drink and Prime NAD+, to target three primary pillars of daily health.

Restore, Rebuild, Reset

Step one: Wake up feeling restored. Isotonix OPC-3 Powder Drink and Isotonix Activated B-Complex Powder Drink contribute to total-body balance. OPCs act like the body’s courier, delivering a healthy flow of blood to the body and, with it, oxygen to tissues. Your muscles, brain, heart and more depend on sufficient oxygen to sustain function. Oxygen is the linchpin in promoting the health of the cell and subsequently oxidative balance within the body. Why do you care about creating oxidative balance? Because the aging process, regular fitness, diet, detoxification and even your sleep habits all contribute to the production of free radicals that are associated with the development of metabolic and age-related concerns too many of us accept as “normal.” Excessive production of free radicals may accelerate the aging process and may even be the reason you don’t wake up feeling ready to tackle your day. You’ve heard the saying “Get up and get your blood pumping,” and that’s the power of Pycnogenol^↠in Isotonix OPC-3 Powder Drink. It moves blood throughout the body and neutralizes the body of accumulated free radicals. For healthy metabolism, a balance between these two forces is needed; too much of one creates a metabolic imbalance for the other.

Why You Need Antioxidants Now, Not Later

1. Because most of us don’t get enough of what we need from our regular diets alone, identifying additional sources of diverse antioxidants can support normal and healthy physiological processes that occur within the body.
2. Adequate detoxification, fitness, sleep and stress support require a balance of both antioxidant creation and free radical quenching.
3. For optimal health, including energy, healthy body composition and cognitive health, it is important to start early and assist your cellular defense system.

You want to start your day ready to combat free radicals and eradicate factors that expend your oxygen. OPCs are powerful free-radical scavengers, and sufficient oxygen is at the root of how they work. In addition, Isotonix OPC-3 is a great source of polyphenols (a type of antioxidant found in dark berries, nuts and tree barks). Polyphenols are critical for the balance of the body’s gut metabolism as well as its response to immune and endocrine (hormonal) balance. This makes Isotonix OPC-3 Powder Drink pair perfectly with Isotonix Activated B-Complex Powder Drink for a healthy start to your day.

The b-complex vitamins are the body’s engineers, responsible for hundreds of bodily biochemical reactions. A B-complex vitamin is a mixture of eight essential B vitamins that are critical to metabolism at the cellular level. Isotonix Activated B-Complex Powder Drink fuels optimal energy production. Vitamin B is involved in promoting proper neurotransmitter activity in the brain and supporting the maintenance of cells, particularly those in the nervous system and intestinal tract. While OPCs clear the way for healthy cells by bringing oxygen to the tissue and neutralizing free radicals, the b-complex vitamins are fueling numerous metabolic processes in the body. 

With the introduction of OPCs and b vitamins in the morning, you send potent nutrient signals to your heart, endocrine system and muscles for optimal function. By taking these two products together in the morning, you’re creating a synergy for production of sufficient energy and neurotransmitter activity and may assist in stabilizing blood sugar levels*. In addition, Isotonix Activated B-Complex Powder drink contains the active forms of vitamins B6, B12 and folic acid. This means that the vitamins do not need to be enzymatically activated prior to utilization by the body, leading to more efficient absorption to start your day off right.

Step two: Rebuild with Prime NAD+ and Isotonix Activated B-Complex Powder Drink. NAD is the body’s architect, responsible for building a strong and well-thought-out blueprint for how your cells function and what instructions you give the rest of the body. These instructions are rooted in your DNA, and the quality of those instructions (or gene expression) is rooted in NAD production in the body. The coenzyme NAD is found in nearly every cell in our bodies. It plays a crucial role in maintaining cellular regeneration and healthy aging while supporting metabolic health in the face of aging and lifestyle factors. As we age and are exposed to metabolic stressors such as processed food, excess sugar, lack of fitness and lack of healthy sleep, our natural production of NAD declines, especially in energy-dependent cells. On the flip side, research indicates that individuals with higher health scores or healthier metabolic markers tend to have higher levels of NAD production when compared to those with lower health scores.

NAD is the currency of energy in your body’s cells. It’s about transforming your energy, remodeling the cell for healthy aging and preserving the healthy messaging our cells received in our younger years to create or maintain a healthy body in later years. Just like your finances, investing in health today creates a better future. NAD keeps your body’s cells in proper balance and drives our bodies toward optimal functioning by taking old or less functional components in a cell and recycling them; it’s like turning back the clock on aging by supporting your skin, brain and body to remain youthful. The essence of vitality and the promise of youth, Prime NAD+ delivers pure nicotinamide riboside and pterostilbene, ensuring your body receives the best in cellular care.

Isotonix Activated B-Complex Powder Drink also supports your body at the cellular level. Specifically, the B vitamin folic acid assists in the normal utilization of amino acids, the building blocks of proteins. Folic acid also supports the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions.  We need Prime NAD+ (the architect) and Isotonix Activated B-Complex Powder Drink (the engineer) to redirect our cells in creating and implementing a healthy plan because life tends to get in the way. We overwhelm our natural rhythms or, worse, we send the wrong signals at the wrong times of the day. We ignore signals to rest our bodies and our brains in the pursuit of productivity. We ignore signals to eat or to stop eating. We ignore signals to sleep or exercise on a schedule. By supplementing NAD and B vitamins prior to our midday meal, we’re able to balance the signals in the midday.  NAD plays an important role in healthy mitochondrial function, and vitamin B5 detoxifies brain tissue and relieves physical and emotional stress. By using Prime NAD+ and Isotonix Activated B-Complex Powder Drink in the late morning, you support ongoing activity and energy expenditure by sending a powerful signal to the cell —even when your daily health plan veers off track.

Step three: Reset your clock with Isotonix OPC-3 Powder Drink OPC-3 is the body’s courier, helping to maintain healthy blood flow and thus supporting oxygen supply to muscles. An additional capful in the evening or before dinner allows the body to take steps to replenish and repair for the next day. Because your body receives light and dark signals (chronobiology or circadian rhythm), it is also sensitive to deviation from regulation of light and dark signals. When we skip our signals to sleep, keep the lights on too bright, eat late at night or take our digital devices to bed, we are disrupting a healthy rhythm in the body that is necessary for processes like reaching deep sleep, waking up with a healthy blood sugar response, hormone release, eating habits, digestion and body temperature. Isotonix OPC-3 Powder Drink’s potent antioxidants support overall cardiovascular health and healthy blood flow.

Why is it important to take these three core products for health?
OPCs (oligomeric proanthocyanidins), such as the ones provided in Isotonix OPC-3 Powder Drink, are critical for neutralizing toxins found in our environment as well as those created during exercise or due to aging. They promote healthy blood flow, meaning that your cells receive the oxygen they need for energy. In combination, Prime NAD+ and Isotonix Activated B-Complex Powder Drink help fuel cellular energy and restoration. Isotonix Activated B-Complex provides activated forms of vitamins B6, B12 and folic acid, which makes them readily available for your body to use in increasing energy and reducing stress.  Ending the day with OPC-3 means not only better productivity the next day, but also a body primed to take on everyday stressors. These three products were meticulously designed to meet our body's needs, offering a path to enriched health and youthful aging. From Isotonix OPC-3's unparalleled antioxidant properties to Isotonix Activated B-Complex's broad-spectrum health benefits and Prime NAD+'s cellular rejuvenation — this range redefines supplements. It's not just about taking supplements; it’s about creating a synergistic effect that can profoundly impact one's health and support the total body’s axis. 

* This product(s) is not registered under the Pharmacy and Poisons Ordinance or the Chinese Medicine Ordinance. Any claim made for it has not been subject to evaluation for such registration. This product is not intended to diagnose, treat or prevent any disease.

†Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

Gluten-Free – The finished product contains no detectible gluten*

No Detectable GMOs – The finished product contains no detectable genetically modified organisms.

Quality Standards – GMP Operations and Standardized Ingredients.

Checked For – Heavy metals, microbiological contaminants, allergens, residual solvents, potency and identity.

*USA FDA classifies gluten-free as a finished product containing less than 20PPM gluten

Prime NAD+^™

Nicotinamide Riboside (crystalline nicotinamide riboside chloride): 250 mg
Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD+. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD+. NAD+ is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying elections between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.

Pterostilbene: 50 mg
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.

Isotonix OPC-3^® Powder Drink

Grape Seed Extract: 25 mg
Grape seed extract are seeds typically from red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). The OPCs are also present in a wide variety of fruits and vegetables, including pine bark (Pycnogenol®) and green tea, where, like grape seed extract, they possess antioxidant properties. These antioxidants help protect cells from free-radical damage, and promote cardiovascular health and vision health. Grape seed extract is extremely rich in polyphenols, a compound that’s high in antioxidants.

Red Wine Extract: 25 mg
Red wine extract is a naturally occurring antioxidant. It occurs naturally in grape vines, roots, seeds and stalks, with its highest concentration in the skins. Red wine is significantly higher in antioxidant properties than in white wine. This brings up the concept of the French-paradox. In the late 1990s, scientists took note of a phenomenon among the French. There were and still are very high rates of heart health in the provinces where residents ate higher fat foods and drank red wine. The protective properties of red wine are believed to have protected the health of the heart. In test tube and animal studies, red wine extract helped blood vessels remain open and flexible.

Pine Bark Extract (Pycnogenol^®): 25 mg
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of Pycnogenol. The extract has three basic properties — it’s a powerful antioxidant, it selectively binds to collagen and elastin, and it aids in the production of endothelial nitric oxide which promotes healthy vasodilation of blood vessels.

As one of the most potent natural scavengers of free radicals, Pycnogenol mops-up all kinds of aggressive radicals before they cause any damage via oxidative stress. Its antioxidant capabilities also appears to help strengthen blood vessel walls and capillaries. It helps maintain healthy circulation and cell vitality.

Today, Pycnogenol is one of the most researched ingredients in the natural product marketplace.

Bilberry Extract: 25 mg
Bilberry extract is derived from the fruit of a common European shrub closely related to the blueberry.

Extracts of the ripe fruit are known to contain flavonoid pigments known as anthocyanins. These pigments act as antioxidants. Scientific studies have shown that bilberry may help to support healthy vision and veins. Bilberry extract also appears to strengthen capillaries and arteries.

Citrus Bioflavonoid Complex: 25 mg
Bioflavonoids are found in certain plants and act as light filters protecting the delicate DNA chains and other important macromolecules of the plant by absorbing ultraviolet radiation.

Isotonix^® Activated B-Complex Powder Drink

Vitamin B12 (Methylcobalamin): 120 mcg 
Vitamin B12 (cobalamin) is a bacterial product naturally found in animal products, especially organ meats such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 is important in homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health.  Deficiencies of the vitamins folic acid, pyridoxine (B6) or cobalamin (B12) can result in elevated levels of homocysteine). Folate and B12, in their active coenzyme form are both necessary cofactors for the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine. 

Methylcobalamin is one of the naturally occurring forms of vitamin B12 found in the human body. The liver must convert cyanocobalamin, the form of B12 most commonly used in supplements, into methylcobalamin before it can be properly utilized by the body; methylcobalamin is more effective than non-active forms of vitamin B12.  Methylcobalamin also assists in the formation of SAMe (S-adenosylmethionine), a nutrient that has powerful mood-elevating properties.  

Folic Acid: 432 mcg 
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans, peas and Brewer’s yeast are the best sources. Folic acid boosts the benefits of B12 supplementation. These two B vitamins join forces and work together in maintaining normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.

Vitamin B2 (Riboflavin-5-Phosphate): 3 mg 
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin B2 serves as a coenzyme, working with other B vitamins. It promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth. It supports healthy skin, nails, hair growth. Vitamin B2 plays a crucial role in turning food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to their higher caloric needs. Vitamin B2 also aids in the breakdown of fats. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts. It must be replenished daily.

Vitamin B6 (Pyridoxal-5-Phosphate): 6 mg
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 is a co-factor required for protein and amino acid metabolism and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells which keeps our body healthy. Vitamin B6 is required for hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to enhance mental function, specifically mood. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be administered as a part of a complex of other B-vitamins for best results.

Potassium: 94 mg 
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also plays a role in a wide variety of biochemical and physiological processes. Among other things, potassium promotes the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy and the synthesis of nucleic acids.

In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium promotes normal muscle relaxation and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium is important in releasing energy from protein, fat and carbohydrates during metabolism. Potassium helps regulate water balance, aids in recovery from exercise and helps with the elimination of wastes. Sodium and potassium are two of the most important ions in maintaining the homeostatic equilibrium of the body fluids.

Vitamin B1 (Thiamin HCl): 2 mg
Thiamin promotes normal carbohydrate metabolism and nerve function.  Thiamin is required for a healthy nervous system, and supports the production of certain neurotransmitters which have an important role in muscle function. It supports the digestive process, increases energy and helps promote mental clarity.

Vitamin B5 (Calcium Pantothenate): 20 mg
Pantothenic acid (B5) promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin because it detoxifies brain tissue, helps relieve physical and emotional stress.

Vitamin B3 (Niacinamide): 20 mg
Niacin is a water-soluble vitamin necessary for many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It is also important for the conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals. 

Biotin: 300 mcg
Biotin can be found in food sources such as egg yolks, peanuts, beef liver, milk, cereals, almonds and Brewer’s yeast. Biotin promotes healthy cell growth, the production of fatty acids, metabolism of fats and amino acids. It supports the citric acid cycle, which is the process in which energy is generated during exercise. Biotin is often recommended for strengthening hair and nails.

These 9 ingredients combined with the superior delivery of Isotonix create a powerhouse B vitamin product superior to the rest on the market. Isotonix Activated B-Complex Powder Drink delivers all of the B vitamins along with select minerals and electrolytes to help boost energy, decrease stress, improve mood, and much more. The activated forms of select vitamins and ensure maximal utilization by the body for optimal results. 

1. When is the most optimal time to take these products?
   There are suggested times to take products to increase effectiveness. Core 3 Health is designed as a three-step daily system. Step 1: When you wake up, take two capfuls of Isotonix OPC-3 Powder Drink and two capfuls of Isotonix Activated B-Complex Powder Drink. Step 2: Take Prime NAD+ and an additional capful of Isotonix Activated B-Complex in the morning before lunch. Step 3: Take a capful of Isotonix OPC-3^® Powder Drink before your evening meal. Each of these supplements has a specialized part to play in your body’s health. Taking them as a 1, 2, 3 system will maximize the benefits to your health.
   
   
2. What is the advantage to taking this trifecta of products regularly?
   Making Core 3 Health part of your daily routine helps regulate your circadian rhythm. Healthy circadian rhythms promote metabolic health, may support healthy sleep and may help combat the cellular aging process.
   
   
3. Does Core 3 Health still work even if I work second or third shift?
   Core 3 Health is designed to rebalance the circadian rhythm of the body. For the most part, circadian rhythm is affected by light and darkness. If you work during the nighttime, you will still follow a 1, 2, 3 schedule with Core 3 Health. Step 1: Take two capfuls of Isotonix OPC-3 Powder Drink and two capfuls of Isotonix Activated B-Complex Powder Drink when you wake up. Step 2: Take Prime NAD+ and one capful of Isotonix Activated B-Complex before lunch. Step 3: Take one capful of Isotonix OPC-3 Powder Drink before your evening meal.
   
   
4. What makes Isotonix OPC-3 Powder Drink unique?
   Delivered in an isotonic state, Isotonix OPC-3 Powder Drink is easily and quickly absorbed into the bloodstream. The combination of bilberry, grape seed and red wine extracts, as well as the clinically validated pine bark extract (Pycnogenol^â†) and citrus extract bioflavonoids, provides powerful antioxidant protection. Isotonix OPC-3 Powder Drink is a vegan formula that contains the clinically studied Pycnogenol, one of the most powerful natural scavengers of free radicals, which may also support cardiovascular health, maintain healthy blood vessel dilation and help maintain joint flexibility. Learn more about Isotonix OPC-3 Powder Drink.
   
   ^†Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.
   
   

5. What makes Isotonix Activated B-Complex Powder Drink unique?
   B vitamins support hundreds of bodily biochemical reactions and need to be replenished daily. Isotonix Activated B-Complex Powder Drink delivers metabolically active forms of several vitamins and minerals in isotonic form, ensuring that your body receives and uses vital nutrients quickly and efficiently. B vitamins, such as B6, B12 and folic acid, must undergo chemical changes before they can be utilized by the body. If the non-active forms are used, the body is forced to work harder to gain the full benefit of the vitamin. By utilizing both the activated form of these vitamins, as well as the superior Isotonix delivery system, Isotonix Activated B-complex Powder Drink supports your body's absorption and immediate use of beneficial ingredients. It’s both gentle on the stomach and crucial to health of the brain, our muscles, stress and energy. Learn more about Isotonix Activated B-Complex Powder Drink.
   
   
6. What makes Prime NAD+ unique?
   NAD, a coenzyme essential for carrying out cellular and metabolic functions, supports the body’s cellular regeneration process and healthy mitochondrial metabolism. Prime NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health. Learn more about Prime NAD+.
   
   
7. Why is there sugar in Isotonix products?
   The sugars found in the Isotonix line help to make the solution isotonic (similar to your body’s natural fluids). Being isotonic, it improves the delivery of nutrients to absorption sites to maximize the absorption into the bloodstream. Our unique Isotonix delivery system is designed to ensure maximum absorption, targeting aging right at its core—inside every cell and within the gut. 

Isotonix OPC-3^® Powder Drink

• Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013 Aug;24(8):1415-22. doi: 10.1016/j.jnutbio.2013.05.001. PMID: 23849454.
• Dueñas M, Muñoz-González I, Cueva C, Jiménez-Girón A, Sánchez-Patán F, Santos-Buelga C, Moreno-Arribas MV, Bartolomé B. A survey of modulation of gut microbiota by dietary polyphenols. Biomed Res Int. 2015;2015:850902. doi: 10.1155/2015/850902. Epub 2015 Feb 22. PMID: 25793210; PMCID: PMC4352430
• Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
• Kumar Singh A, Cabral C, Kumar R, Ganguly R, Kumar Rana H, Gupta A, Rosaria Lauro M, Carbone C, Reis F, Pandey AK. Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients. 2019 Sep 13;11(9):2216. doi: 10.3390/nu11092216. PMID: 31540270; PMCID: PMC6770155.
• Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
• Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
• Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
• Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
• Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
• Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Williamson G, Sheedy K. Effects of Polyphenols on Insulin Resistance. Nutrients. 2020 Oct 14;12(10):3135. doi: 10.3390/nu12103135. PMID: 33066504; PMCID: PMC7602234.
  
  

Prime^™ NAD+

• Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
• Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
• What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important
• Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
• Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
• Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodly https://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/
• ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
• Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
• Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74. 
• Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018). 
• de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021. 
• Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. 
• Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916. 
• Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010 Mar 31;11(4):1365-402. doi: 10.3390/ijms11041365. PMID: 20480025; PMCID: PMC2871121.
• Kim Y, Keogh JB, Clifton PM. Polyphenols and Glycemic Control. Nutrients. 2016 Jan 5;8(1):17. doi: 10.3390/nu8010017. PMID: 26742071; PMCID: PMC4728631.
• Maiese K. Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. Curr Neurovasc Res. 2017;14(3):299-304. doi: 10.2174/1567202614666170718092010. PMID: 28721811; PMCID: PMC5600856.
• Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018. 
• Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357. 
• Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485. 
• Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316. 
• Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87. 
• Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78. 
  
  

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• Benton D., et al.  Thiamine supplementation for mood and cognitive functioning.  Psychopharmacology. 129(1):66-71, 1997.
• Benton, D., et al.  The effects of nutrients on mood.  Public Health Nutr.  2(3A):403-409, 1999.
• Bhagavan, H. N., et al.  The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children.  Pediatrics.  55(3):437-441, 1975.
• Bronstrup A, Hages M, Prinz-Langenohl R, Pietrzik K. Effects of folic acid and 
• Bryan, J., et al.  Associations between dietary intake of folate and vitamins B-12 and B-6 and self-reported cognitive function and psychological well-being in Australian men and women in midlife.  J Nutr Health Aging.  8(4):226-232, 2004.
• Bryan, J., et al.  Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages.  Journal of Nutrition.  132(6):1345-1356, 2002.
• combinations of folic acid and vitamin B12 on plasma homocysteine concentrations in healthy young women. Am J Clin Nutr 68:1104-10, 1998. 
• Coppen, A., et al.  Plasma folate and affective morbidity during long-term lithium therapy.  Br J Psychiatry.  141:87-89, 1982.
• Cummings, P. M., et al.  Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease.  J Am Coll Cardiol.  36:758-765, 2000.
• Dharmarajan, T. S., et al.  Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.  Geriatrics.  58(3):30-34, 2003.
• Doshi, S. N., et al.  Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.  Circulation.  105(1):22-26, 2002.
• Duthie, S. J., et al.  Homocysteine, B vitamin status, and cognitive function in the elderly.  American Journal of Clinical Nutrition.  75(5):908-913, 2002.
• Friso, S., et al.  Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk.  Am J Clin Nutr.  79(6):992-998, 2004.
• Grant, J. E., et al.  Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.  J Am Diet Assoc.  96(4):383-386, 1996.
• Hartvig, P., et al.  Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with position emission tomography.  Neural Trans.  102:91-97, 1995.
• Heap, L. C., et al.  Vitamin B status in patients with chronic fatigue syndrome.  J R Soc Med.  92(4):183-185, 1999.
• Heseker, H., et al.  Psychological disorders as early symptoms of a mild-to-moderate vitamin deficiency.  Ann N Y Acad Sci.  669:352-357, 1992.
• Jacobson, W., et al.  Serum folate and chronic fatigue syndrome.  Neurology.  43:2645-2647, 1993.
• Kelly, G. S.  Nutritional and botanical interventions to assist with the adaptation to stress.  Alternative Medicine Review.4(4):249-265, 1999.
• Litoff, D., et al.  Effects of pantothenic acid supplementation on human exercise.  Med Sci Sport Exercise., 17(Supplement):287, 1985.
• Osada, K., et al.  Experimental study of fatigue provoked by biotin deficiency in mice.  Int J Vitam Nutr Res.  74(5):334-340, 2004.
• Quadri, P., et al.  Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia.  Am J Clin Nutr.  80(1):114-122, 2004.
• Riggs, K. M., et al.  Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.  American Journal of Clinical Nutrition.  63(3):306-314, 1996.
• Van den Berg M., et al.  Combined vitamin B-6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.  Journal Vascular Surgery.  20(6):933-940, 1994.
• van Oort FV, Melse-Boonstra A, Brouwer IA, et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study. 77:1318-23, 2003. 
• Vargiu, R., et al.  Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q(10), nicotinamide, riboflavin and pantothenic acid in the rat.  Physiol Behav.  76(2):257-63, 2002.
• Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 61:695-700, 2001. 
• Werbach, M. R.  Nutritional strategies for treating chronic fatigue syndrome.  Alternative Medicine Review.  5(2):93-108, 2000.
• Woo, K. S., et al.  Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation.  American Journal of Medicine.  112(7):535-539, 2002.